Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Vet J. 2021 Aug;274:105696. doi: 10.1016/j.tvjl.2021.105696. Epub 2021 May 26.
Sudden death is one of the most common causes of death in humans in Western countries. Approximately 85% of these cases are of cardiac origin. In dogs and cats, sudden cardiac death (SCD) also commonly occurs, but fewer pathophysiological and prevalence data are available. Both structural, primarily 'electrical' and ischemic heart diseases are known to cause SCD, many of which share similar underlying arrhythmogenic mechanisms between humans and companion animals. As for underlying genetics, numerous mutations on multiple loci have been related to SCD in humans, but only a few mutations associated with dilated cardiomyopathy and SCD have been identified in dogs, e.g. in the phospholamban and titin genes. Information published from human medicine can therefore inform future veterinary studies, but also dogs and cats could act as spontaneous models of SCD in humans. Further research in both fields is therefore warranted to better understand the pathophysiology, genetics, and prevention of SCD.
猝死是西方国家人类死亡的最常见原因之一。这些病例中约有 85%是心源性的。在犬猫中，也常发生心源性猝死（SCD），但可获得的病理生理学和患病率数据较少。已知结构性疾病，主要是“电”和缺血性心脏病都会导致 SCD，其中许多疾病在人类和伴侣动物之间具有相似的潜在心律失常机制。至于潜在的遗传学，在人类中已经有许多与 SCD 相关的多个基因座的突变，但在犬中仅发现少数与扩张型心肌病和 SCD 相关的突变，例如在肌浆网磷酸转运蛋白和肌联蛋白基因中。因此，来自人类医学的已发表信息可以为未来的兽医研究提供信息，但犬猫也可以作为人类 SCD 的自发性模型。因此，这两个领域都需要进一步的研究，以更好地理解 SCD 的病理生理学、遗传学和预防。
