Department of Psychological & Brain Sciences, Boston University, 900 Commonwealth Avenue, 2nd Floor, Boston, MA, 02215, USA.
AIDS Behav. 2021 Dec;25(Suppl 3):314-332. doi: 10.1007/s10461-021-03346-1. Epub 2021 Jun 19.
This paper examines the contributions of laboratory-based alcohol challenge research (ACR) to the development of HIV prevention interventions. Following a brief overview of HIV prevention interventions and related health behavior change models, we discuss how alcohol may influence mechanisms of behavior change. The paper highlights the value of ACR for: (1) elucidating mechanisms of action through which alcohol affects sexual risk behavior, (2) testing how alcohol may influence mechanisms thought to underlie HIV prevention interventions, (3) clarifying moderators of the causal influences of alcohol, (4) identifying novel intervention targets, and (5) developing strategies to reduce sexual risk among those who consume alcohol. We conclude with a discussion of the importance of using experimental research to identify mechanisms of behavior change that are specific to populations at high risk for HIV and outline some key implications for developing HIV prevention interventions that integrate the role of alcohol.
本文探讨了基于实验室的酒精挑战研究（ACR）对艾滋病病毒预防干预措施发展的贡献。在简要概述艾滋病病毒预防干预措施和相关健康行为改变模型之后，我们讨论了酒精如何影响行为改变的机制。本文强调了 ACR 的以下价值：（1）阐明酒精影响性行为风险的作用机制；（2）检验酒精如何影响被认为是艾滋病病毒预防干预措施基础的机制；（3）阐明酒精因果影响的调节因素；（4）确定新的干预目标；（5）制定策略以减少饮酒者的性风险。最后，我们讨论了使用实验研究来确定针对艾滋病毒高危人群的行为改变机制的重要性，并概述了制定将酒精作用纳入其中的艾滋病病毒预防干预措施的一些关键影响。
