可变聚腺苷酸化相关基因座解析人类特征和疾病。
Alternative polyadenylation-associated loci interpret human traits and diseases.
机构信息
Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
出版信息
Trends Genet. 2021 Sep;37(9):773-775. doi: 10.1016/j.tig.2021.06.002. Epub 2021 Jun 17.
Alternative polyadenylation (APA)-associated genetic variants have been proposed to impact diverse human phenotypes and disorders. In a recent study, Li et al. established a landscape of 3'-untranslated region (UTR) APA quantitative trait loci (3'aQTLs) across multiple human tissues, revealing substantial 3'aQTLs that contribute to complex human traits and diseases.
交替多聚腺苷酸化 (APA) 相关的遗传变异被认为会影响多种人类表型和疾病。在最近的一项研究中，Li 等人在多个人类组织中建立了 3'-非翻译区 (UTR) APA 数量性状基因座 (3'aQTL) 的图谱，揭示了大量的 3'aQTL 对复杂的人类特征和疾病有影响。
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