Triflimide-Promoted Nucleophilic C-Arylation of Halopurines to Access N-Substituted Purine Biaryls.

Functionalized nucleobases are utilized in a wide range of fields; therefore, the development of new synthesis methods is essential for their continued application. With respect to the C-arylation of halopurines, which possess a substituent at the N-position, only a small number of successful cases have been reported, which is predominately a result of large steric hinderance effects. Herein, we report efficient and metal-free C-arylations and SAr reactions of N-substituted chloropurines in aromatic and heteroatom nucleophiles promoted by triflimide (TfNH) in fluoroalcohol.