通过铜催化的酰胺化反应合成6,7,8-三取代嘌呤。

Synthesis of 6,7,8-trisubstituted purines via a copper-catalyzed amidation reaction.

作者信息

Ibrahim Nada, Legraverend Michel

机构信息

UMR 176, Institut Curie, Bât. 110-112, Centre Universitaire, 91405 Orsay, France.

出版信息

J Org Chem. 2009 Jan 2;74(1):463-5. doi: 10.1021/jo802248g.

DOI:10.1021/jo802248g

PMID:19012431

Abstract

We report herein an efficient method for the synthesis of 6,7,8-trisubstituted purines via a copper-catalyzed amidation reaction from easily accessible starting materials. Furthermore, the resulting 6-benzylsulfanyl-substituted purine derivatives may be readily oxidized for substitution by nucleophiles to give access to 6,7,8-trisubstituted purines for biological screening purposes.

摘要

我们在此报告一种通过铜催化的酰胺化反应，由易于获得的起始原料合成6,7,8-三取代嘌呤的有效方法。此外，所得的6-苄硫基取代的嘌呤衍生物可易于氧化，以便被亲核试剂取代，从而获得用于生物筛选目的的6,7,8-三取代嘌呤。