Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan.
Laboratory of Veterinary Radiology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan.
J Vet Med Sci. 2021 Aug 6;83(8):1206-1211. doi: 10.1292/jvms.21-0060. Epub 2021 Jun 18.
Tegafur is a prodrug of fluoropyrimidine 5-fluorouracil (5-FU), while TS-1 is an oral fixed-dose combination of three active drugs, tegafur, gimeracil, and oteracil. This pilot study evaluated the safety of tegafur/gimeracil/oteracil in the treatment of cancers in dogs. Tegafur/gimeracil/oteracil was administered orally at a mean dose of 1.1 mg/kg twice daily on alternate days, Monday-Wednesday-Friday, every week to 11 dogs with tumors. Partial response and stable disease were observed in one dog each, whereas six exhibited progressive disease. Three dogs were not assessed. Adverse events, the most serious being grade 2, were noted in seven dogs. Adverse events were acceptable, and the drug was effective in some dogs. Therefore, tegafur/gimeracil/oteracil may be useful for treating malignant solid tumors in canines.
替加氟是氟尿嘧啶 5-氟尿嘧啶(5-FU)的前体药物,而替吉奥胶囊是三种活性药物替加氟、吉美嘧啶和奥替拉西的口服固定剂量复方制剂。本初步研究评估了替加氟/吉美嘧啶/奥替拉西治疗犬癌症的安全性。替加氟/吉美嘧啶/奥替拉西以平均剂量 1.1 mg/kg 每日两次,每两周周一至周三和周五给药,共治疗 11 只患有肿瘤的犬。1 只犬出现部分缓解和稳定疾病,6 只犬出现进展性疾病。3 只犬未进行评估。7 只犬出现不良事件,最严重的为 2 级。不良事件可接受,且该药物对一些犬有效。因此,替加氟/吉美嘧啶/奥替拉西可能对治疗犬的恶性实体肿瘤有用。