术中吖啶橙光动力疗法和筛状电子束照射治疗犬鼻内肿瘤：一项初步研究。
Intraoperative acridine orange photodynamic therapy and cribriform electron-beam irradiation for canine intranasal tumors: A pilot study.
作者信息
Maruo Takuya, Nagata Koichi, Fukuyama Yasuhiro, Nemoto Yuki, Kawarai Shinpei, Fujita Yukihiro, Nakayama Tomohiro
机构信息
Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama).
出版信息
Can Vet J. 2015 Dec;56(12):1232-8.
Untreated canine intranasal tumors carry a poor prognosis. We retrospectively evaluated the efficacy of marginal tumor resection in combination with intraoperative acridine orange (AO) photodynamic therapy (PDT) and 1 fraction of 5 Gy megavoltage irradiation for canine intranasal malignant tumors. When cribriform plate invasion or turbinate destruction around the cribriform plate was present, an additional fraction of 20 Gy was delivered with an electron beam during surgery. The study included 6 dogs, 2 of which were classified as stage I, 1 as stage II, and 3 as stage IV. The median local disease-free survival time and overall survival after the treatment were 8.5 and 13 months, respectively. Recurrence was noted in 2 of the 6 dogs after 4 and 7 months. Adverse events were mild (subcutaneous emphysema in 1 case, and rhinitis in 3 cases). Combination AO therapy may increase the tumor control time of dogs with marginally resectable intranasal malignant tumors.
未经治疗的犬鼻内肿瘤预后较差。我们回顾性评估了边缘性肿瘤切除联合术中吖啶橙（AO）光动力疗法（PDT）以及单次5 Gy兆伏放疗对犬鼻内恶性肿瘤的疗效。当存在筛板侵犯或筛板周围鼻甲破坏时，术中用电子束追加20 Gy的剂量。该研究纳入了6只犬，其中2只为I期，1只为II期，3只为IV期。治疗后的中位局部无病生存时间和总生存时间分别为8.5个月和13个月。6只犬中有2只分别在4个月和7个月后出现复发。不良事件较轻（1例皮下气肿，3例鼻炎）。联合AO治疗可能会延长犬鼻内边缘可切除恶性肿瘤的肿瘤控制时间。
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