人类对屋尘螨变应原的免疫反应。特应性和非特应性受试者抗体的同型分析。

Human immune response to allergens of house dust mite, Dermatophagoides pteronyssinus. Isotypic analysis of antibodies in atopic and non-atopic subjects.

作者信息

Saint-Remy J M, Lebrun P M, Lebecque S J, Masson P L

机构信息

Experimental Medicine Unit, Université Catholique de Louvain, Brussels, Belgium.

出版信息

Allergy. 1988 Jul;43(5):338-47. doi: 10.1111/j.1398-9995.1988.tb00427.x.

DOI:10.1111/j.1398-9995.1988.tb00427.x

PMID:3414913

Abstract

Specific antibodies isolated by immunoabsorption on four main insolubilized allergens from Dermatophagoides pteronyssinus (DPT) had the following isotypic distribution: in 16 atopic patients, 52% IgG, 40% IgM, 8% IgA, 0.1% IgE and, in 12 non-atopic individuals, 48% IgG, 46% IgM, 6% IgA, 0.03% IgE. The ratios between geometric means of antibody values in each class (atopic vs non-atopics) were 2.4 for IgG, 2.0 for IgM, 2.8 for IgA and 66.7 for IgE. The amount of anti-DPT antibodies in IgG subclasses did not follow the usual distribution of total IgG subclasses, i.e., IgG1 greater than IgG2 greater than IgG3 greater than IgG4. In atopics the order was IgG2 greater than IgG1 greater than IgG4 greater than IgG3 and in non-atopics, IgG4 greater than IgG1 = IgG2 greater than IgG3 although 6/12 of the latter had no detectable (less than 0.5 micrograms/ml plasma) IgG4.

摘要

通过免疫吸附从粉尘螨（DPT）的四种主要不溶性变应原中分离出的特异性抗体具有以下同种型分布：在16名特应性患者中，IgG占52%，IgM占40%，IgA占8%，IgE占0.1%；在12名非特应性个体中，IgG占48%，IgM占46%，IgA占6%，IgE占0.03%。每类抗体值的几何平均值（特应性与非特应性）之比，IgG为2.4，IgM为2.0，IgA为2.8，IgE为66.7。IgG亚类中抗DPT抗体的量并不遵循总IgG亚类的通常分布，即IgG1＞IgG2＞IgG3＞IgG4。在特应性个体中，顺序为IgG2＞IgG1＞IgG4＞IgG3；在非特应性个体中，顺序为IgG4＞IgG1 = IgG2＞IgG3，尽管后者中有6/12检测不到（血浆中＜0.5微克/毫升）IgG4。