Ruiz R G, Kemeny D M, Mariani F, Price J F
Department of Child Health, King's College School of Medicine and Dentistry, Denmark Hill, London.
Arch Dis Child. 1992 Aug;67(8):1023-6. doi: 10.1136/adc.67.8.1023.
Responses to the house dust mite during infancy may be important determinants of asthma in susceptible individuals. This study assessed early IgG subclass antibody responses to Dermatophagoides pteronyssinus in children of atopic parents. Sixteen atopic and 15 non-atopic children were selected from a birth cohort, and atopic status was established according to follow up over the first two years. IgG1 and IgG4 antibodies to D pteronyssinus were measured by enzyme linked immunosorbent assay at 7 days and 3, 6, 12, and 24 months. In all children D pteronyssinus IgG1 fell at 3 months (indicating maternal antibody loss), rose progressively to 12 months, and waned at 24 months. D pteronyssinus IgG4 was only detectable at 7 days. Children who were atopic by 2 years and therefore at greater risk of asthma, tended to have higher D pteronyssinus IgG1 at 6 and 12 months. These data suggest greater exposure or responsiveness to dust mite during infancy than in the second year.
婴儿期对屋尘螨的反应可能是易感个体患哮喘的重要决定因素。本研究评估了特应性父母的子女对尘螨的早期IgG亚类抗体反应。从一个出生队列中选取了16名特应性儿童和15名非特应性儿童，并根据头两年的随访确定特应性状态。在7天、3、6、12和24个月时，通过酶联免疫吸附测定法测量针对尘螨的IgG1和IgG4抗体。在所有儿童中，尘螨IgG1在3个月时下降（表明母体抗体消失），逐渐上升至12个月，并在24个月时减弱。尘螨IgG4仅在7天时可检测到。到2岁时患有特应性疾病且因此患哮喘风险更高的儿童，在6个月和12个月时往往具有更高的尘螨IgG1。这些数据表明，婴儿期比第二年对尘螨的接触或反应性更高。
