McLoughlin C, Nesbitt G A, Howe J P
Mater Infirmorum Hospital, Belfast, Northern Ireland.
Anaesthesia. 1988 Jul;43(7):565-7. doi: 10.1111/j.1365-2044.1988.tb06689.x.
Eighty-four fit, unpremedicated patients who presented for routine surgery and received a standard anaesthetic technique were allocated randomly to three equal groups. Group 1 received tubocurarine 0.05 mg/kg before induction of anaesthesia. Group 2 received soluble aspirin 600 mg orally one hour before surgery, while Group 3 received no pretreatment. Aspirin prophylaxis produced a significant reduction in the incidence of subsequent suxamethonium-induced myalgia and the improvement was similar to that achieved with tubocurarine pretreatment. Pre-operative oral administration of aspirin effectively reduces muscle pains and avoids many of the complications associated with pretreatment with non-depolarising agents.
84名身体健康、未接受术前用药、接受常规手术并采用标准麻醉技术的患者被随机分为三组，每组人数相等。第一组在麻醉诱导前接受0.05mg/kg的筒箭毒碱。第二组在手术前1小时口服600mg可溶性阿司匹林，而第三组未进行预处理。阿司匹林预防措施显著降低了随后琥珀酰胆碱诱导的肌痛发生率，其改善效果与筒箭毒碱预处理相似。术前口服阿司匹林可有效减轻肌肉疼痛，并避免许多与非去极化剂预处理相关的并发症。
