Chestnutt W N, Lowry K G, Dundee J W, Pandit S K, Mirakhur R K
Anaesthesia. 1985 Mar;40(3):263-9. doi: 10.1111/j.1365-2044.1985.tb10753.x.
In a randomised double-blind trial carried out on fit, unpremedicated patients undergoing standard minor operations with early postoperative mobility, using a standard form of anaesthesia, pretreatment with diazepam 0.15 mg/kg or midazolam 0.1 mg/kg failed to reduce significantly the incidence of postoperative muscle pains following suxamethonium 1 mg/kg. By contrast, tubocurarine 0.05 mg/kg proved to be effective as a pretreatment. Neither benzodiazepine influenced the incidence or severity of fasciculations seen with suxamethonium or the duration of neuromuscular block. Tubocurarine virtually abolished visible fasciculation and, in the dose used, reduced the intensity and duration of the neuromuscular block. There were no clinically significant changes in serum potassium, creatinine phosphokinase or aldolase after suxamethonium, although 5 out of 47 showed an atypical rise in creatinine phosphokinase.
在一项针对健康、未用术前药且术后早期可活动的患者进行标准小手术的随机双盲试验中，采用标准麻醉方式，术前给予0.15 mg/kg地西泮或0.1 mg/kg咪达唑仑，未能显著降低1 mg/kg琥珀酰胆碱术后肌痛的发生率。相比之下，0.05 mg/kg筒箭毒碱作为术前用药被证明是有效的。两种苯二氮䓬类药物均未影响琥珀酰胆碱引起的肌束震颤的发生率或严重程度，也未影响神经肌肉阻滞的持续时间。筒箭毒碱几乎消除了可见的肌束震颤，并且在所使用的剂量下，缩短了神经肌肉阻滞的强度和持续时间。琥珀酰胆碱给药后，血清钾、肌酸磷酸激酶或醛缩酶无临床显著变化，尽管47例中有5例肌酸磷酸激酶出现非典型升高。
