Duan Yu, Chen Ji, Cui Hong, Zhao Cuijuan
Department of Gastroenterology, The Third Hospital of Inner Mongolia Medical University (Inner Mongolia Baogang Hospital) Baotou 014010, Inner Mongolia Autonomous Region, China.
Am J Transl Res. 2021 May 15;13(5):5484-5490. eCollection 2021.
To explore the effect of pantoprazole and somatostatin combined with thrombin in the treatment of non-esophagogastric varicosity upper gastrointestinal bleeding (UGB) as well as its influence on serum hs-CRP and coagulation function.
From June 2016 to May 2018, patients with upper gastrointestinal hemorrhage due to non-esophagogastric varices in our hospital were selected as research subjects. After screening, they were randomly divided into the combined group (57 cases) and the control group (57 cases). After the two groups are treated, the therapeutic effect was observed. The two groups of patients were followed up for 6 consecutive months, and the data were statistically analyzed.
It was found that there wass no significant difference between the two groups in gender, age, amount of bleeding, and etiology (P > 0.05). It was found that the immediate hemostasis rate and the hemostasis rate within 24 hours in the combined group were distinctly higher compared to the control group. The difference has statistical significance (P < 0.05). The total effective rate of the combined group was distinctly higher compared to the control group (P < 0.05). By comparing the expression levels of hs-CRP and IL-6 protein in the serum of the two groups before and after treatment, it was found that there was no significant difference in the expression levels of hs-CRP and IL-6 protein before treatment. However, after treatment, it was found that the levels of hs-CRP and IL-6 protein in the combined group were distinctly lower compared to the control group (P < 0.05). By analyzing adverse reactions, it was found that the combined group had distinctly lower adverse reactions compared to the control group (P < 0.05).
This work provides an experimental basis for the diagnosis and treatment of non-esophagogastric varicose UGB in the clinic.
探讨泮托拉唑、生长抑素联合凝血酶治疗非食管胃静脉曲张性上消化道出血（UGB）的效果及其对血清超敏C反应蛋白（hs-CRP）和凝血功能的影响。
选取2016年6月至2018年5月我院非食管胃静脉曲张性上消化道出血患者作为研究对象。经筛选后，将其随机分为联合组（57例）和对照组（57例）。两组治疗后，观察治疗效果。对两组患者连续随访6个月，并对数据进行统计学分析。
发现两组在性别、年龄、出血量及病因方面无显著差异（P＞0.05）。发现联合组的即时止血率和24小时内止血率明显高于对照组。差异具有统计学意义（P＜0.05）。联合组的总有效率明显高于对照组（P＜0.05）。通过比较两组治疗前后血清中hs-CRP和白细胞介素-6（IL-6）蛋白的表达水平，发现治疗前hs-CRP和IL-6蛋白的表达水平无显著差异。然而，治疗后发现联合组中hs-CRP和IL-6蛋白的水平明显低于对照组（P＜0.05）。通过分析不良反应，发现联合组的不良反应明显低于对照组（P＜0.05）。
本研究为临床非食管胃静脉曲张性UGB的诊断和治疗提供了实验依据。
