Maeda T, Okawa T, Ujihara H, Akita Y, Miyaji N, Nishijima H, Tanaka M, Kita M, Ikeda M, Kusakabe K
Department of Radiology, Tokyo Women's Medical College.
Gan To Kagaku Ryoho. 1988 Aug;15(8 Pt 2):2366-9.
RI-angiography with 99mTc microsphere albumin (MISA) was performed to evaluate the distribution during intra-arterial infusion chemotherapy from October 1985 to November 1987 at Tokyo Women's Medical College. Thirty studies were carried out in twenty-one patients with oropharyngeal (11), oral cavity (6), maxillary sinus (3) and laryngeal cancer (1). Six mCi of 99mTc-MISA was slowly injected through the intra-arterial catheter in 1-2 minutes. The evaluation of RI-distribution was classified into the following three categories: Excellent, all of the tumor are covered; Good, more than 50% of the tumor; Poor, less than 50% of the tumor. Good or excellent distribution was obtained in 18 of 21 cases (86%). Sequential perfusion studies were performed on 8 cases. Three cases had evidenced excellent or good distribution during the treatment. Five cases showed poor distribution in the first study. In three of these cases, distributions were improved after replacement of the catheter, RI-distribution at the internal carotid arterial area was seen in three patients, and in two of them, excellent or good distribution was obtained after replacement of the catheter. These data suggested that RI angiography with 99mTc-MISA was useful for evaluation of the drug distribution during intra-arterial infusion chemotherapy, especially for detection of abnormal distribution in the internal carotid arterial area.
1985年10月至1987年11月期间，在东京女子医科大学进行了用99mTc微球白蛋白（MISA）进行放射性核素血管造影，以评估动脉内灌注化疗期间的药物分布情况。对21例口咽癌（11例）、口腔癌（6例）、上颌窦癌（3例）和喉癌（1例）患者进行了30项研究。将6毫居里的99mTc-MISA在1至2分钟内通过动脉内导管缓慢注入。放射性核素分布的评估分为以下三类：优秀，肿瘤全部被覆盖；良好，肿瘤覆盖超过50%；差，肿瘤覆盖少于50%。21例中有18例（86%）获得了良好或优秀的分布。对8例患者进行了连续灌注研究。3例在治疗期间显示出优秀或良好的分布。5例在首次研究中显示分布较差。其中3例在更换导管后分布得到改善，3例患者在内颈动脉区域可见放射性核素分布，其中2例在更换导管后获得了优秀或良好的分布。这些数据表明，用99mTc-MISA进行放射性核素血管造影有助于评估动脉内灌注化疗期间的药物分布，特别是用于检测内颈动脉区域的异常分布。
