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日本血液系统疾病患者院内 COVID-19 感染的临床特征和相关危险因素。

Clinical characteristics and risk factors associated with nosocomial COVID-19 infection in patients with hematological disorders in Japan.

机构信息

Eiju General Hospital, 2-23-16, Higashi-Ueno, Taito, Tokyo, Japan.

出版信息

Int J Hematol. 2021 Dec;114(6):719-724. doi: 10.1007/s12185-021-03172-0. Epub 2021 Jun 21.

Abstract

Patients with cancer are considered at high risk of acquiring coronavirus disease (COVID-19). To identify patients who are likely to be diagnosed with severe COVID-19, we analyzed the risk factors for mortality in patients admitted to the hematology department at our institute. The mortality rate of all patients was as high as 62% (21 of the 34 patients), and most of these patients had malignant malignancies. Patients before an achievement of remission had a 10.8-fold higher risk of death than those in remission. The group receiving chemotherapy with steroids had a shorter survival time and had an 8.3-fold higher risk of death than that receiving chemotherapy without steroids. During the COVID-19 pandemic, it is necessary to carefully monitor or follow-up patients with active diseases and patients receiving steroid-containing chemotherapy.

摘要

癌症患者被认为感染冠状病毒病(COVID-19)的风险很高。为了确定可能被诊断为严重 COVID-19 的患者,我们分析了我院血液科住院患者的死亡危险因素。所有患者的死亡率高达 62%(34 名患者中有 21 名),其中大多数患者患有恶性肿瘤。未缓解的患者的死亡风险是缓解患者的 10.8 倍。接受含激素化疗的患者的生存时间更短,死亡风险比接受不含激素化疗的患者高 8.3 倍。在 COVID-19 大流行期间,有必要仔细监测或随访患有活动性疾病和接受含激素化疗的患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed0e/8215476/4b02750012f0/12185_2021_3172_Fig1_HTML.jpg

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