Helen Wills Neuroscience Institute, University of California, Berkeley, United States; Wellcome Centre for Integrative Neuroimaging, University of Oxford, United Kingdom.
Experimental Psychology, University College London, United Kingdom; Ipsos, Brisbane, Queensland, Australia.
Neuroimage. 2021 Oct 1;239:118286. doi: 10.1016/j.neuroimage.2021.118286. Epub 2021 Jun 18.
How much of the functional organization of our visual system is inherited? Here we tested the heritability of retinotopic maps in human visual cortex using functional magnetic resonance imaging. We demonstrate that retinotopic organization shows a closer correspondence in monozygotic (MZ) compared to dizygotic (DZ) twin pairs, suggesting a partial genetic determination. Using population receptive field (pRF) analysis to examine the preferred spatial location and selectivity of these neuronal populations, we estimate a heritability around 10-20% for polar angle preferences and spatial selectivity, as quantified by pRF size, in extrastriate areas V2 and V3. Our findings are consistent with heritability in both the macroscopic arrangement of visual regions and stimulus tuning properties of visual cortex. This could constitute a neural substrate for variations in a range of perceptual effects, which themselves have been found to be at least partially genetically determined. These findings also add convergent evidence for the hypothesis that functional map topology is linked with cortical morphology.
我们的视觉系统的功能组织有多少是遗传的？在这里，我们使用功能磁共振成像来测试人类视觉皮层中视网膜图的遗传性。我们证明，同卵（MZ）双胞胎之间的视网膜组织比异卵（DZ）双胞胎之间更一致，这表明部分遗传决定因素的存在。使用群体感受野 (pRF) 分析来检查这些神经元群体的首选空间位置和选择性，我们估计在 V2 和 V3 等外纹状区中，极角偏好和空间选择性的遗传率约为 10-20%，这可通过 pRF 大小来量化。我们的发现与视觉区域的宏观排列和视觉皮层的刺激调谐特性的遗传性一致。这可能构成一系列知觉效应变化的神经基础，而这些知觉效应本身至少部分是由遗传决定的。这些发现还为功能图拓扑与皮质形态相关的假设提供了有力的证据。
