Haroske G, Bergander S, König R
Carl Gustav Carus Medical Academy, Institute of Pathological Anatomy, Dresden.
Arch Geschwulstforsch. 1988;58(3):159-68.
Nowadays the existence of malignancy associated changes in the epithelium of the cervix uteri is commonly accepted. There are some differences in the view about the nature of these changes. Some hints were given by previous studies for the epithelial changes to exhibit possibly early preneoplastic aspects. In this study subvisually morphologic changes were detected in intermediate cells of the cervical smears by means of image analysis (ZYPAB-3-system). Our investigations on 117 patients suffering from cervical neoplasias as well as healthy controls have shown that the malignancy associated changes are not only limited to about two third of patients with cervical neoplasias but also existent in close to a fourth of healthy women. Those healthy people are considered to be at higher risk for developing a cervical neoplasia than other healthy women.
如今，子宫颈上皮中存在与恶性肿瘤相关的变化已被普遍接受。关于这些变化的性质，存在一些不同观点。先前的研究给出了一些线索，表明上皮变化可能呈现早期癌前病变特征。在本研究中，通过图像分析（ZYPAB - 3系统）在宫颈涂片的中间细胞中检测到亚视觉形态学变化。我们对117例患有宫颈肿瘤的患者以及健康对照者的研究表明，与恶性肿瘤相关的变化不仅局限于约三分之二的宫颈肿瘤患者，还存在于近四分之一的健康女性中。这些健康人被认为比其他健康女性患宫颈肿瘤的风险更高。
