de Boer Rudolf A, Aboumsallem Joseph Pierre, Bracun Valentina, Leedy Douglas, Cheng Richard, Patel Sahishnu, Rayan David, Zaharova Svetlana, Rymer Jennifer, Kwan Jennifer M, Levenson Joshua, Ronco Claudio, Thavendiranathan Paaladinesh, Brown Sherry-Ann
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Cardiooncology. 2021 Jun 21;7(1):24. doi: 10.1186/s40959-021-00110-1.
Increasing evidence suggests a multifaceted relationship exists between cancer and cardiovascular disease (CVD). Here, we introduce a 5-tier classification system to categorize cardio-oncology syndromes (COS) that represent the aspects of the relationship between cancer and CVD. COS Type I is characterized by mechanisms whereby the abrupt onset or progression of cancer can lead to cardiovascular dysfunction. COS Type II includes the mechanisms by which cancer therapies can result in acute or chronic CVD. COS Type III is characterized by the pro-oncogenic environment created by the release of cardiokines and high oxidative stress in patients with cardiovascular dysfunction. COS Type IV is comprised of CVD therapies and diagnostic procedures which have been associated with promoting or unmasking cancer. COS Type V is characterized by factors causing systemic and genetic predisposition to both CVD and cancer. The development of this framework may allow for an increased facilitation of cancer care while optimizing cardiovascular health through focused treatment targeting the COS type.
越来越多的证据表明，癌症与心血管疾病（CVD）之间存在多方面的关系。在此，我们引入一种五级分类系统，对心脏肿瘤综合征（COS）进行分类，这些综合征代表了癌症与CVD关系的各个方面。COS I型的特征是癌症的突然发作或进展可导致心血管功能障碍的机制。COS II型包括癌症治疗可导致急性或慢性CVD的机制。COS III型的特征是心血管功能障碍患者中因心脏因子释放和高氧化应激而产生的促癌环境。COS IV型由与促进或揭示癌症相关的CVD治疗和诊断程序组成。COS V型的特征是导致CVD和癌症的全身和遗传易感性的因素。该框架的开发可能有助于在通过针对COS类型的针对性治疗优化心血管健康的同时，提高癌症护理的便利性。
