Fertility Clinic, Horsens Regional Hospital, Horsens, Denmark.
Research Unit for Mental Public Health, Department of Public Health, Aarhus University, Aarhus, Denmark.
Acta Obstet Gynecol Scand. 2021 Oct;100(10):1849-1857. doi: 10.1111/aogs.14215. Epub 2021 Jul 12.
Long-term growth has been poorly investigated in boys and girls born to parents receiving fertility treatment. This study aimed to investigate the growth of children born following fertility treatment up to adulthood hypothesizing comparable growth in children born to parents receiving fertility treatment or to subfertile parents conceiving spontaneously to that in children spontaneously conceived by fertile parents.
In this historical long-term follow-up study the study population consisted of 4151 singletons born at term in the Aarhus Birth Cohort between 1990 and 1992. Parental lifestyle and sociodemographic characteristics together with multiple measurements of weight and height were collected up to 20 years of age (6.1% of children contributed with at least one measurement for height or weight at age 20 years). The main outcome was difference in z-score for height (m) and weight (kg) between children conceived spontaneously (reference) and children conceived following fertility treatment, children conceived spontaneously by subfertile parents, or unplanned. Results were adjusted for pre-pregnancy maternal and paternal body mass index, maternal educational level, smoking during pregnancy, maternal age, and parity.
Singletons conceived following fertility treatment (n = 164; 4.0%) or by subfertile parents (n = 271; 6.5%) had comparable magnitude of weight estimates to children conceived spontaneously (difference in z-score per year 0.0148 [95% CI 0.0026-0.0270] and 0.0069 [95% CI -0.0028 to 0.0165], respectively). Height estimates were also comparable between groups of children conceived following fertility treatment or by subfertile parents (difference in z-score per year 0.0022 [95% CI -0.0075 to 0.0119]) compared with children conceived spontaneously (difference in z-score per year -0.0026 (95% CI -0.0103 to 0.0052). From the beginning of adolescence, we found lower weight for children born to subfertile parents and to parents receiving fertility treatment compared with spontaneously conceived children.
The main finding was equal long-term growth for children born at term by parents who received fertility treatment or parents waiting more than 12 months to conceive compared with spontaneously conceived children.
对于接受生育治疗的父母所生的男孩和女孩，其长期生长情况研究甚少。本研究旨在通过假设接受生育治疗的父母所生孩子的生长情况与自然受孕但生育能力较低的父母所生孩子或自然受孕的父母所生孩子的生长情况相当，来调查接受生育治疗的父母所生孩子的生长情况。
在这项历史悠久的长期随访研究中，研究人群由 1990 年至 1992 年在奥胡斯出生队列中足月出生的 4151 名单胎组成。收集了父母的生活方式和社会人口统计学特征以及多次体重和身高测量值，直至 20 岁（6.1%的儿童至少有一次在 20 岁时测量身高或体重）。主要结局是自发受孕（参照）和生育治疗后受孕、生育能力较低的父母自然受孕或计划外受孕的儿童之间身高（m）和体重（kg）z 分数的差异。结果根据受孕前母亲和父亲的体重指数、母亲的教育水平、孕期吸烟、母亲年龄和产次进行了调整。
接受生育治疗（n=164；4.0%）或由生育能力较低的父母（n=271；6.5%）受孕的单胎儿童的体重估计值与自然受孕儿童相当（每年 z 分数差异 0.0148 [95%CI 0.0026-0.0270] 和 0.0069 [95%CI -0.0028 至 0.0165]）。接受生育治疗或生育能力较低的父母受孕的儿童的身高估计值也与自然受孕儿童相当（每年 z 分数差异 0.0022 [95%CI 0.0075 至 0.0119]），与自然受孕儿童相比（每年 z 分数差异 -0.0026 [95%CI -0.0103 至 0.0052]）。从青春期开始，我们发现生育能力较低的父母和接受生育治疗的父母所生的儿童的体重比自然受孕的儿童低。
主要发现是，与自然受孕的儿童相比，通过接受生育治疗的父母或等待 12 个月以上才受孕的父母足月出生的儿童的长期生长情况相当。
