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经阴道二维超声测量宫颈容积预测引产结局的前瞻性观察研究。

Transvaginal two-dimensional ultrasound measurement of cervical volume to predict the outcome of the induction of labour: a prospective observational study.

机构信息

North Colombo Teaching Hospital, Ragama, Sri Lanka.

Castle Street Hospital for Women, Colombo, Sri Lanka.

出版信息

BMC Pregnancy Childbirth. 2021 Jun 22;21(1):433. doi: 10.1186/s12884-021-03929-9.

DOI:10.1186/s12884-021-03929-9
PMID:34158010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8218494/
Abstract

BACKGROUND

Assessing the likelihood of success of induction of labour using ultrasonically measured cervical volume is an important research question.

METHOD

A prospective observational study was carried out at North Colombo Teaching Hospital, Ragama, Sri Lanka. Pre-induction digital cervical assessment, transvaginal cervical length, and cervical volume measurements were performed. Inductions with singleton pregnancies at term were included. Basic demographic and clinical details, independent variables (Bishop score, cervical length and cervical volume), and dependent variables (frequency of delivery within 24 h and induction to delivery interval) were recorded. Vaginal delivery within 24 h was the primary outcome.

RESULTS

We studied 100 pregnant women who had induction of labour. Median (IQR) Bishop score was 5 (3-6), mean (SD) cervical length was 3.6 (0.7) cm, and mean (SD) cervical volume was 27.5 (10.4) cm. Cervical length was the best predictor for predicting the likelihood of vaginal delivery within 24 h [aOR - 12.12 (3.44, 42.71); < 0.001], and cervical volume also appeared to be a significant potential predictor [aOR-1.10 (1.01, 1.17); 0.01]. Cervical length was found to have the highest AUC (0.83) followed by the cervical volume (0.74). The best cut-off value for cervical volume in predicting the likelihood of vaginal delivery within 24 h was less than 28.5 cm with a sensitivity of 72% and specificity of 74%.

CONCLUSIONS

Transvaginal sonographic measurement of cervical volume appears to be a potential novel predictor for the likelihood of vaginal delivery within 24 h of induction of labour. Cervical length is still more superior to cervical volume in predicting the likelihood of vaginal delivery. Bishop score was not a significant predictor in this context.

摘要

背景

评估经超声测量宫颈容积诱导分娩成功的可能性是一个重要的研究问题。

方法

在斯里兰卡拉嘎玛的北科伦坡教学医院进行了一项前瞻性观察研究。进行了诱导前数字宫颈评估、经阴道宫颈长度和宫颈容积测量。纳入了足月单胎妊娠的引产。记录了基本的人口统计学和临床细节、自变量(Bishop 评分、宫颈长度和宫颈容积)和因变量(24 小时内分娩的频率和引产至分娩的间隔)。24 小时内阴道分娩是主要结局。

结果

我们研究了 100 名接受引产的孕妇。中位数(IQR)Bishop 评分为 5(3-6),平均(SD)宫颈长度为 3.6(0.7)cm,平均(SD)宫颈容积为 27.5(10.4)cm。宫颈长度是预测 24 小时内阴道分娩可能性的最佳预测指标[aOR-12.12(3.44,42.71);<0.001],宫颈容积似乎也是一个重要的潜在预测指标[aOR-1.10(1.01,1.17);0.01]。宫颈长度的 AUC(0.83)最高,其次是宫颈容积(0.74)。预测 24 小时内阴道分娩可能性的宫颈容积最佳截断值小于 28.5cm,灵敏度为 72%,特异性为 74%。

结论

经阴道超声测量宫颈容积似乎是预测引产 24 小时内阴道分娩可能性的潜在新指标。在预测阴道分娩的可能性方面,宫颈长度仍然优于宫颈容积。Bishop 评分在这种情况下不是一个显著的预测指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb06/8218494/dd334a631c37/12884_2021_3929_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb06/8218494/dd334a631c37/12884_2021_3929_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb06/8218494/dd334a631c37/12884_2021_3929_Fig1_HTML.jpg

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经曲马多预处理后,罗哌卡因硬膜外分娩镇痛的半数有效剂量(ED50)和 95%有效剂量(ED95)分别为 2.12(95%置信区间:1.54-2.90)μg/ml 和 4.60(95%置信区间:3.23-6.26)μg/ml。
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