IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Cancer Immunol Res. 2021 Aug;9(8):855. doi: 10.1158/2326-6066.CIR-21-0424. Epub 2021 Jun 22.
Complement activation contributes to tumor progression in several cancer types. In this issue, Daugan and colleagues propose complement component C1s and C4d as new markers of prognosis in clear cell renal cell carcinoma. The mechanism of action of C1s involves both canonical and intracellular, noncanonical functions. The results provide new molecular targets to prevent tumor escape from immune surveillance, which leads to tumor progression..
补体激活有助于几种癌症类型的肿瘤进展。在本期杂志中，Daugan 及其同事提出补体成分 C1s 和 C4d 是透明细胞肾细胞癌预后的新标志物。C1s 的作用机制涉及经典和细胞内非经典功能。研究结果提供了新的分子靶点，以防止肿瘤逃避免疫监视，从而导致肿瘤进展。
