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Pathologic von Willebrand factor degradation is a major contributor to left ventricular assist device-associated bleeding: pathophysiology and evolving clinical management.

作者信息

Bartoli Carlo R

机构信息

Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

出版信息

Ann Cardiothorac Surg. 2021 May;10(3):389-392. doi: 10.21037/acs-2020-cfmcs-29.

DOI:10.21037/acs-2020-cfmcs-29
PMID:34159121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8185388/
Abstract
摘要

相似文献

1
Pathologic von Willebrand factor degradation is a major contributor to left ventricular assist device-associated bleeding: pathophysiology and evolving clinical management.病理性血管性血友病因子降解是左心室辅助装置相关出血的主要原因：病理生理学及不断发展的临床管理
Ann Cardiothorac Surg. 2021 May;10(3):389-392. doi: 10.21037/acs-2020-cfmcs-29.
2
Pathologic von Willebrand factor degradation with a left ventricular assist device occurs via two distinct mechanisms: mechanical demolition and enzymatic cleavage.左心室辅助装置导致病理性血管性血友病因子降解是通过两种不同的机制发生的：机械破坏和酶切。
J Thorac Cardiovasc Surg. 2015 Jan;149(1):281-9. doi: 10.1016/j.jtcvs.2014.09.031. Epub 2014 Sep 18.
3
Reduced continuous-flow left ventricular assist device speed does not decrease von Willebrand factor degradation.降低连续流左心室辅助装置的速度并不会降低血管性血友病因子的降解。
J Thorac Cardiovasc Surg. 2016 Jun;151(6):1747-1754.e1. doi: 10.1016/j.jtcvs.2016.01.031. Epub 2016 Jan 30.
4
Decreased RPM reduces von Willebrand factor degradation with the EVAHEART LVAS: implications for device-specific LVAD management.降低转速可减少EVAHEART左心室辅助系统中血管性血友病因子的降解：对特定设备的左心室辅助装置管理的启示
J Card Surg. 2020 Jul;35(7):1477-1483. doi: 10.1111/jocs.14620.
5
In vitro comparison of the hemocompatibility of two centrifugal left ventricular assist devices.两种离心式左心室辅助装置体外血液相容性比较。
J Thorac Cardiovasc Surg. 2019 Feb;157(2):591-599.e4. doi: 10.1016/j.jtcvs.2018.07.085. Epub 2018 Aug 6.
6
Inhibition of ADAMTS-13 by Doxycycline Reduces von Willebrand Factor Degradation During Supraphysiological Shear Stress: Therapeutic Implications for Left Ventricular Assist Device-Associated Bleeding.强力霉素抑制 ADAMTS-13 可减少超高生理切应力下 von Willebrand 因子的降解：左心室辅助装置相关出血的治疗意义。
JACC Heart Fail. 2015 Nov;3(11):860-9. doi: 10.1016/j.jchf.2015.06.016. Epub 2015 Oct 7.
7
Clinical and In Vitro Evidence That Left Ventricular Assist Device-Induced von Willebrand Factor Degradation Alters Angiogenesis.左心室辅助装置诱导的血管性血友病因子降解改变血管生成的临床和体外证据。
Circ Heart Fail. 2018 Sep;11(9):e004638. doi: 10.1161/CIRCHEARTFAILURE.117.004638.
8
Anticoagulation strategy in a patient on the HeartMate III® left ventricular assist device with acquired von Willebrand syndrome and recurring gastrointestinal bleeding episodes: sometimes less is more.一名使用HeartMate III®左心室辅助装置且患有获得性血管性血友病综合征并反复出现胃肠道出血事件的患者的抗凝策略：有时少即是多。
Eur J Cardiothorac Surg. 2020 Apr 1;57(4):796-798. doi: 10.1093/ejcts/ezz165.
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Preclinical Models for Translational Investigations of Left Ventricular Assist Device-Associated von Willebrand Factor Degradation.左心室辅助装置相关血管性血友病因子降解的转化研究临床前模型
Artif Organs. 2015 Jul;39(7):569-75. doi: 10.1111/aor.12428. Epub 2015 Mar 21.
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Von Willebrand factor in patients on mechanical circulatory support - a double-edged sword between bleeding and thrombosis.接受机械循环支持患者的血管性血友病因子——出血与血栓形成之间的双刃剑
Kardiochir Torakochirurgia Pol. 2015 Sep;12(3):233-7. doi: 10.5114/kitp.2015.54459. Epub 2015 Sep 28.

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Advancing LVAD Technology: Overcoming Challenges and Shaping the Future of Mechanical Circulatory Support.推进左心室辅助装置技术：克服挑战，塑造机械循环支持的未来。
J Clin Med. 2024 Dec 20;13(24):7813. doi: 10.3390/jcm13247813.
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Hemocompatibility and biophysical interface of left ventricular assist devices and total artificial hearts.左心室辅助装置和全人工心脏的血液相容性和生物物理界面。
Blood. 2024 Feb 22;143(8):661-672. doi: 10.1182/blood.2022018096.
3
Loss of pulsatility with continuous-flow left ventricular assist devices and the significance of the arterial endothelium in von-Willebrand factor production and degradation.左心室辅助装置连续血流中的搏动丧失与血管内皮在血管性血友病因子产生和降解中的意义。
Artif Organs. 2023 Apr;47(4):640-648. doi: 10.1111/aor.14456. Epub 2022 Nov 20.
4
ADAMTS13 inhibition to treat acquired von Willebrand syndrome during mechanical circulatory support device implantation.在机械循环支持装置植入期间用 ADAMTS13 抑制物治疗获得性血管性血友病综合征。
J Thromb Haemost. 2022 Dec;20(12):2797-2809. doi: 10.1111/jth.15889. Epub 2022 Oct 17.

本文引用的文献

1
Toward a Standard Practice to Quantify von Willebrand Factor Degradation During Left Ventricular Assist Device Support.针对左心室辅助装置支持期间 von Willebrand 因子降解的标准化实践。
Ann Thorac Surg. 2021 Oct;112(4):1257-1264. doi: 10.1016/j.athoracsur.2020.09.039. Epub 2020 Nov 20.
2
A Novel Toroidal-Flow Left Ventricular Assist Device Minimizes Blood Trauma: Implications of Improved Ventricular Assist Device Hemocompatibility.一种新型的环形流左心室辅助装置可最大程度地减少血液创伤：改善心室辅助装置血液相容性的意义。
Ann Thorac Surg. 2019 Jun;107(6):1761-1767. doi: 10.1016/j.athoracsur.2018.11.053. Epub 2018 Dec 23.
3
Clinical and In Vitro Evidence That Left Ventricular Assist Device-Induced von Willebrand Factor Degradation Alters Angiogenesis.左心室辅助装置诱导的血管性血友病因子降解改变血管生成的临床和体外证据。
Circ Heart Fail. 2018 Sep;11(9):e004638. doi: 10.1161/CIRCHEARTFAILURE.117.004638.
4
von Willebrand factor regulation of blood vessel formation.血管生成中 von Willebrand 因子的调节。
Blood. 2018 Jul 12;132(2):132-140. doi: 10.1182/blood-2018-01-769018. Epub 2018 Jun 4.
5
Arterial Pulsatility and Circulating von Willebrand Factor in Patients on Mechanical Circulatory Support.机械循环支持患者的动脉脉动性和循环血管性血友病因子。
J Am Coll Cardiol. 2018 May 15;71(19):2106-2118. doi: 10.1016/j.jacc.2018.02.075.
6
Clinical and In Vitro Evidence That Subclinical Hemolysis Contributes to LVAD Thrombosis.临床和体外证据表明亚临床溶血有助于 LVAD 血栓形成。
Ann Thorac Surg. 2018 Mar;105(3):807-814. doi: 10.1016/j.athoracsur.2017.05.060. Epub 2017 Sep 21.
7
von Willebrand factor disruption and continuous-flow circulatory devices.血管性血友病因子的破坏与连续流循环装置。
J Heart Lung Transplant. 2017 Nov;36(11):1155-1163. doi: 10.1016/j.healun.2017.06.004. Epub 2017 Jun 12.
8
Continuous-Flow LVAD Support Causes a Distinct Form of Intestinal Angiodysplasia.持续血流左心室辅助装置可导致独特类型的肠血管发育不良。
Circ Res. 2017 Sep 29;121(8):963-969. doi: 10.1161/CIRCRESAHA.117.310848. Epub 2017 Jul 20.
9
Reduced continuous-flow left ventricular assist device speed does not decrease von Willebrand factor degradation.降低连续流左心室辅助装置的速度并不会降低血管性血友病因子的降解。
J Thorac Cardiovasc Surg. 2016 Jun;151(6):1747-1754.e1. doi: 10.1016/j.jtcvs.2016.01.031. Epub 2016 Jan 30.
10
Inhibition of ADAMTS-13 by Doxycycline Reduces von Willebrand Factor Degradation During Supraphysiological Shear Stress: Therapeutic Implications for Left Ventricular Assist Device-Associated Bleeding.强力霉素抑制 ADAMTS-13 可减少超高生理切应力下 von Willebrand 因子的降解：左心室辅助装置相关出血的治疗意义。
JACC Heart Fail. 2015 Nov;3(11):860-9. doi: 10.1016/j.jchf.2015.06.016. Epub 2015 Oct 7.