School of Human Sciences, The University of Western Australia, Crawley, Western Australia, Australia.
Telethon Kids Institute, The University of Western Australia, Nedlands, Western Australia, Australia.
Physiology (Bethesda). 2021 Jul 1;36(4):256-266. doi: 10.1152/physiol.00042.2020.
Trajectories of airway remodeling and functional impairment in asthma are consistent with the notion that airway pathology precedes or coincides with the onset of asthma symptoms and may be present at birth. An association between intrauterine growth restriction (IUGR) and asthma development has also been established, and there is value in understanding the underlying mechanism. This review considers airway pathophysiology as a consequence of IUGR that increases susceptibility to asthma.
哮喘的气道重塑和功能损伤轨迹与气道病理学先于或与哮喘症状同时发生的观点一致，并且可能在出生时就存在。宫内生长受限 (IUGR) 与哮喘发病之间也存在关联，因此理解其潜在机制具有重要意义。本综述认为，气道病理生理学是 IUGR 的后果，增加了哮喘的易感性。
