Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Clin Breast Cancer. 2021 Jun;21(3):e245-e251. doi: 10.1016/j.clbc.2020.10.001. Epub 2020 Oct 9.
The objective of this study was to investigate the relationship of aerobic fitness (AF) at diagnosis, before treatment and its relationship with body composition, physical function, lipidic profile, comorbidities, tumor characteristics, and quality of life of women with breast cancer (BC) PATIENTS AND METHODS: This cross-sectional cohort study included 78 women with BC that were assessed before treatment. A 6-minute walk test was used to evaluate the subjects' AF, estimating the maximum oxygen consumption (VO) to classify the women with BC into 2 groups: good/excellent AF or fair/weak/very weak AF. Dual-energy x-ray absorptiometry was performed to assess body composition. The International Global Physical Activity Questionnaire and the Functional Assessment of Cancer Therapy - Fatigue questionnaires were applied to assess the level of physical activity and the quality of life, respectively.
Among the women included, the majority (81%) had the luminal subtype of BC. Most of the women were diagnosed with T1/T2 tumors and with negative axillary lymph nodes. We found that women with BC with good/excellent AF (VO = 32.9 ± 6.0 mL/kg/min) presented significantly lower weight, body mass index, abdominal circumference, percentual and total body fat, and bone mineral density compared with women with fair/weak/very weak AF (VO = 21.8 ± 6.9 mL/kg/min). Also, women with BC with good/excellent AF showed better performance on physical functional tests. No relationship between estimated VO and comorbidities, tumor characteristics, or quality of life was found.
AF is a predictor of body composition and physical function in women with BC. These data suggest that women with BC with higher AF can decrease the chance of adverse effects during BC treatment.
本研究旨在探讨诊断时、治疗前有氧运动能力（AF）与身体成分、身体功能、血脂谱、合并症、肿瘤特征和乳腺癌（BC）患者生活质量之间的关系。
本横断面队列研究纳入了 78 名接受治疗前评估的 BC 女性患者。6 分钟步行试验用于评估受试者的 AF，估计最大摄氧量（VO）将 BC 女性分为 2 组：良好/优秀 AF 或一般/虚弱/非常虚弱 AF。双能 X 射线吸收法用于评估身体成分。国际全球体力活动问卷和癌症治疗功能评估-疲劳问卷分别用于评估身体活动水平和生活质量。
在纳入的女性中，大多数（81%）为管腔型 BC。大多数女性诊断为 T1/T2 肿瘤且腋窝淋巴结阴性。我们发现，具有良好/优秀 AF（VO=32.9±6.0 mL/kg/min）的 BC 女性体重、体重指数、腰围、体脂肪百分比和总量以及骨矿物质密度显著低于一般/虚弱/非常虚弱 AF（VO=21.8±6.9 mL/kg/min）的女性。此外，具有良好/优秀 AF 的 BC 女性在身体功能测试中表现更好。未发现估计 VO 与合并症、肿瘤特征或生活质量之间存在关系。
AF 是 BC 女性身体成分和身体功能的预测指标。这些数据表明，AF 较高的 BC 女性在 BC 治疗期间发生不良反应的可能性较低。
