血浆 IL-12/IFN-γ 轴可预测认知正常老年人的认知轨迹。
Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults.
机构信息
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
出版信息
Alzheimers Dement. 2022 Apr;18(4):645-653. doi: 10.1002/alz.12399. Epub 2021 Jun 23.
INTRODUCTION
Immune dysregulation is implicated in neurodegeneration and altered cytokine levels are seen in people with dementia. However, whether cytokine levels are predictive of cognitive decline in cognitively unimpaired (CU) elderly, especially in the setting of elevated amyloid beta (Aβ), remains unclear.
METHODS
We measured nine cytokines in the baseline plasma of 298 longitudinally followed CU elderly and assessed whether these measures were associated with cognitive decline, alone or synergistically with Aβ. We next examined associations between cytokine levels and neuroimaging biomarkers of Aβ/tau/neurodegeneration.
RESULTS
Higher IL-12p70 was associated with slower cognitive decline in the setting of higher Aβ (false discovery rate [FDR] = 0.0023), whereas higher IFN-γ was associated with slower cognitive decline independent of Aβ (FDR = 0.013). Higher IL-12p70 was associated with less tau and neurodegeneration in participants with higher Aβ.
DISCUSSION
Immune dysregulation is implicated in early-stage cognitive decline, and greater IL-12/IFN-γ axis activation may be protective against cognitive decline and early-stage AD progression.
简介
免疫失调与神经退行性变有关，痴呆患者的细胞因子水平发生改变。然而，细胞因子水平是否可预测认知功能正常（CU）老年人的认知能力下降，特别是在淀粉样蛋白β（Aβ）水平升高的情况下，尚不清楚。
方法
我们测量了 298 名纵向随访的 CU 老年人基线血浆中的 9 种细胞因子，并评估了这些指标是否与认知能力下降有关，是否与 Aβ 协同作用。接下来，我们检查了细胞因子水平与 Aβ/tau/神经退行性变的神经影像学生物标志物之间的关联。
结果
在 Aβ 水平较高的情况下，IL-12p70 较高与认知下降速度较慢有关（假发现率 [FDR] = 0.0023），而 IFN-γ 较高与 Aβ 独立的认知下降速度较慢有关（FDR = 0.013）。在 Aβ 水平较高的参与者中，较高的 IL-12p70 与较少的 tau 和神经退行性变有关。
讨论
免疫失调与认知能力下降的早期阶段有关，IL-12/IFN-γ 轴的激活增强可能对认知能力下降和早期 AD 进展具有保护作用。
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