Bratisl Lek Listy. 2021;122(7):449-453. doi: 10.4149/BLL_2021_074.
This study analysed the characteristics and outcome of the patients with bilateral germ testicular cell cancer (TC), especially synchronous.
Among 2.124 TC patients diagnosed between 1970 and 2020, 96 (4. 5%) developed the 2nd TC. Nine occurred synchronously and 87 were metachronous. Patients were analysed according to the age and histological type of bilateral TC in comparison with unilateral TC.
The mean follow-up of all 2,124 patients was 14.9 years. Unilateral TC occurred in 2.028 patients (the mean age of 32.4 years), 707 of them had seminoma, 1.310 nonseminomatous (NS) TC and 11 spermatocytic tumours. The 1st tumour of metachronous bilateral disease was diagnosed at a significantly younger age (27.1 years) compared to the unilateral disease (32.4 years). The mean interval between the 1st and the 2nd TC was 8.2 years. Patients with NSTC had a longer mean interval (9.2 years) between the 1st and the 2nd TC in comparison with seminoma patients (6.7 years). The mean age at diagnosis for seminoma was significantly higher (31.3 years) compared to the NSTC (24.1 years). Bilateral seminoma occurred in 5 synchronous bilateral TC patients, four patients had discordant histology, none presented with bilateral NSTC.
Bilateral TC is a rare and requires individualized management of patients (Tab. 5, Fig. 4, Ref. 32).
本研究分析双侧生殖细胞肿瘤（TC）患者的特征和结局，尤其是双侧 TC 同时发生的情况。
在 1970 年至 2020 年间诊断的 2124 例 TC 患者中，有 96 例（4.5%）发生了第 2 次 TC。其中 9 例为双侧 TC 同时发生，87 例为双侧 TC 异时发生。患者根据双侧 TC 的年龄和组织学类型与单侧 TC 进行比较和分析。
所有 2124 例患者的中位随访时间为 14.9 年。单侧 TC 发生在 2028 例患者中（平均年龄为 32.4 岁），其中 707 例为精原细胞瘤，1310 例为非精原细胞瘤（NS）TC，11 例为精母细胞性肿瘤。异时性双侧疾病的第 1 次肿瘤发生在明显更年轻的年龄（27.1 岁），而单侧疾病为 32.4 岁。第 1 次和第 2 次 TC 之间的平均间隔为 8.2 年。与精原细胞瘤患者相比，NS 肿瘤患者第 1 次和第 2 次 TC 之间的平均间隔更长（9.2 年）。精原细胞瘤的诊断平均年龄明显较高（31.3 岁），而非 NS TC 为 24.1 岁。5 例同时性双侧 TC 患者中双侧均为精原细胞瘤，4 例患者组织学类型不同，无双侧 NS TC 患者。
双侧 TC 较为罕见，需要对患者进行个体化管理（表 5，图 4，参考文献 32）。
