尿液细胞因子与危重症 COVID-19 患者的急性肾损伤相关。
Urinary cytokines correlate with acute kidney injury in critically ill COVID-19 patients.
机构信息
Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden.
Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden.
出版信息
Cytokine. 2021 Oct;146:155589. doi: 10.1016/j.cyto.2021.155589. Epub 2021 May 24.
BACKGROUND
Acute kidney injury is common in COVID-19 patients admitted to the ICU. Urinary biomarkers are a non-invasive way of assaying renal damage, and so far, urinary cytokines are not fully investigated. The current study aimed to assess urinary cytokine levels in COVID-19 patients.
METHODS
Urine was collected from COVID-19 patients (n = 29) in intensive care and compared to a preoperative group of patients (n = 9) with no critical illness. 92 urinary cytokines were analyzed in multiplex using the Olink Target 96 inflammation panel and compared to clinical characteristics, and urinary markers of kidney injury.
RESULTS
There were strong correlations between proinflammatory cytokines and between urinary cytokines and urinary kidney injury markers in 29 COVID-19 patients. Several cytokines were correlated to kidney injury, 31 cytokines to AKI stage and 19 cytokines correlated to maximal creatinine.
CONCLUSIONS
Urinary inflammatory cytokines from a wide range of immune cell lineages were significantly upregulated during COVID-19 and the upregulation correlated with acute kidney injury as well as urinary markers of kidney tissue damage.
背景
COVID-19 患者入住 ICU 后常发生急性肾损伤。尿生物标志物是一种评估肾损伤的非侵入性方法，到目前为止，尿细胞因子尚未得到充分研究。本研究旨在评估 COVID-19 患者的尿细胞因子水平。
方法
从重症监护病房的 COVID-19 患者（n=29）中收集尿液，并与无危重病的术前患者（n=9）进行比较。使用 Olink Target 96 炎症面板对 92 种尿细胞因子进行多重分析，并与临床特征和尿肾损伤标志物进行比较。
结果
在 29 例 COVID-19 患者中，促炎细胞因子之间以及尿细胞因子与尿肾损伤标志物之间存在强烈相关性。一些细胞因子与肾损伤相关，31 种细胞因子与 AKI 分期相关，19 种细胞因子与最大肌酐相关。
结论
COVID-19 期间，广泛的免疫细胞谱系的尿炎症细胞因子显著上调，上调与急性肾损伤以及尿肾组织损伤标志物相关。
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