Ravi K, Teo K K, Kappagoda C T
Department of Medicine, University of Alberta, Edmonton, Canada.
Can J Physiol Pharmacol. 1988 May;66(5):630-6. doi: 10.1139/y88-098.
The effects of pulmonary lymphatic obstruction and pulmonary venous congestion on the activities of slowly adapting receptors (SAR) and rapidly adapting receptors (RAR) of the airways were examined in anaesthetized, artificially ventilated dogs. In 11 out of 12 RAR (12 dogs) examined, pulmonary lymphatic obstruction for a period of 20 min produced a sustained significant increase in activity without a significant change in peak airway pressure and dynamic compliance. The activity remained significantly elevated even after the pulmonary lymphatic obstruction was released. This stimulus was without effect on the SAR (n = 5 dogs). Pulmonary venous congestion alone increased the RAR activity (n = 7 dogs) significantly without producing significant changes in airway mechanics. Lymphatic obstruction, when superimposed upon congestion, did not produce a further significant increase in activity. In four dogs the effect of pulmonary venous congestion (left atrial pressure increased from 7.6 +/- 1.7 to 16.3 +/- 2.7 mmHg) (1 mmHg = 133.3 Pa) on pulmonary lymphatic flow was examined. The procedure caused a significant increase in lymph flow. These results suggest that in the dog, the RAR activity is influenced by changes in the pulmonary extravascular space.
在麻醉、人工通气的犬中，研究了肺淋巴阻塞和肺静脉充血对气道慢适应性感受器（SAR）和快适应性感受器（RAR）活动的影响。在检查的12只犬中的11只RAR中，20分钟的肺淋巴阻塞使活动持续显著增加，而气道峰值压力和动态顺应性无显著变化。即使解除肺淋巴阻塞后，活动仍显著升高。此刺激对SAR无影响（n = 5只犬）。单纯肺静脉充血显著增加RAR活动（n = 7只犬），而气道力学无显著变化。当淋巴阻塞叠加于充血时，活动未进一步显著增加。在4只犬中，研究了肺静脉充血（左心房压力从7.6±1.7升高至16.3±2.7 mmHg）（1 mmHg = 133.3 Pa）对肺淋巴流量的影响。该操作使淋巴流量显著增加。这些结果表明，在犬中，RAR活动受肺血管外间隙变化的影响。
