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中央杏仁核在进食行为中的作用概述。

Overview of the central amygdala role in feeding behaviour.

作者信息

Izadi Mina Sadat, Radahmadi Maryam

机构信息

Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Br J Nutr. 2022 Mar 28;127(6):953-960. doi: 10.1017/S0007114521002312. Epub 2021 Jun 21.

Abstract

The neural regulation of feeding behaviour, as an essential factor for survival, is an important research area today. Feeding behaviour and other lifestyle habits play a major role in optimising health and obesity control. Feeding behaviour is physiologically controlled through processes associated with energy and nutrient needs. Different brain nuclei are involved in the neural regulation of feeding behaviours. Therefore, understanding the function of these brain nuclei helps develop feeding control methods. Among important brain nuclei, there is scant literature on the central amygdala (CeA) nucleus and feeding behaviour. The CeA is one of the critical brain regions that play a significant role in various physiological and behavioural responses, such as emotional states, reward processing, energy balance and feeding behaviour. It contains γ-aminobutyric acid neurons. Also, it is the major output region of the amygdaloidal complex. Moreover, the CeA is also involved in multiple molecular and biochemical factors and has extensive connections with other brain nuclei and their neurotransmitters, highlighting its role in feeding behaviour. This review aims to highlight the significance of the CeA nucleus on food consumption by its interaction with the performance of reward, digestive and emotional systems.

摘要

进食行为的神经调节作为生存的一个重要因素,是当今一个重要的研究领域。进食行为和其他生活方式习惯在优化健康和控制肥胖方面起着重要作用。进食行为通过与能量和营养需求相关的过程受到生理控制。不同的脑核参与进食行为的神经调节。因此,了解这些脑核的功能有助于开发进食控制方法。在重要的脑核中,关于中央杏仁核(CeA)与进食行为的文献很少。CeA是在各种生理和行为反应(如情绪状态、奖赏处理、能量平衡和进食行为)中起重要作用的关键脑区之一。它含有γ-氨基丁酸神经元。此外,它是杏仁复合体的主要输出区域。而且,CeA还涉及多种分子和生化因素,并与其他脑核及其神经递质有广泛联系,凸显了其在进食行为中的作用。本综述旨在通过其与奖赏、消化和情绪系统表现的相互作用,突出CeA核在食物消耗方面的重要性。

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