Kim Joshua, Zhang Xiangyu, Muralidhar Shruti, LeBlanc Sarah A, Tonegawa Susumu
RIKEN-MIT Center for Neural Circuit Genetics at The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
RIKEN-MIT Center for Neural Circuit Genetics at The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Neuron. 2017 Mar 22;93(6):1464-1479.e5. doi: 10.1016/j.neuron.2017.02.034.
Basolateral amygdala (BLA) principal cells are capable of driving and antagonizing behaviors of opposing valence. BLA neurons project to the central amygdala (CeA), which also participates in negative and positive behaviors. However, the CeA has primarily been studied as the site for negative behaviors, and the causal role for CeA circuits underlying appetitive behaviors is poorly understood. Here, we identify several genetically distinct populations of CeA neurons that mediate appetitive behaviors and dissect the BLA-to-CeA circuit for appetitive behaviors. Protein phosphatase 1 regulatory subunit 1B BLA pyramidal neurons to dopamine receptor 1 CeA neurons define a pathway for promoting appetitive behaviors, while R-spondin 2 BLA pyramidal neurons to dopamine receptor 2 CeA neurons define a pathway for suppressing appetitive behaviors. These data reveal genetically defined neural circuits in the amygdala that promote and suppress appetitive behaviors analogous to the direct and indirect pathways of the basal ganglia. VIDEO ABSTRACT.
基底外侧杏仁核（BLA）的主要细胞能够驱动和对抗具有相反效价的行为。BLA神经元投射到中央杏仁核（CeA），后者也参与消极和积极行为。然而，CeA主要被作为消极行为的位点进行研究，而对于CeA回路在欲求行为中所起的因果作用却知之甚少。在此，我们鉴定出几个在基因上不同的CeA神经元群体，它们介导欲求行为，并剖析了BLA到CeA的欲求行为回路。蛋白磷酸酶1调节亚基1B的BLA锥体神经元到多巴胺受体1的CeA神经元定义了一条促进欲求行为的通路，而R-spondin 2的BLA锥体神经元到多巴胺受体2的CeA神经元定义了一条抑制欲求行为的通路。这些数据揭示了杏仁核中由基因定义的神经回路，它们促进和抑制欲求行为，类似于基底神经节的直接和间接通路。视频摘要。
