乙醇与氯贝丁酯在月桂酸羟基化反应中的协同作用。
Synergism of ethanol and clofibrate in the lauric acid hydroxylation.
作者信息
Pazo J A, Parafita M A
机构信息
Department of Physiology, Faculty of Biology, University of Santiago de Compostela, Spain.
出版信息
Drug Alcohol Depend. 1988 May;21(2):137-9. doi: 10.1016/0376-8716(88)90059-2.
The effects of ethanol and clofibrate on lauric acid hydroxylation in isolated rat hepatocytes cultured for 72 h were studied. During culture the lauric acid hydroxylation activity decreases. When the hepatocytes were cultured for 72 h with the addition of 10(-5) M, 10(-4) M and 10(-3) M clofibrate, the lauric acid hydroxylation increased by 42%, 428% and 900%, respectively. The stimulation by ethanol was also significant. The addition of both ethanol and clofibrate to the culture media resulted in a potentiation of this induction.
研究了乙醇和氯贝丁酯对培养72小时的离体大鼠肝细胞中月桂酸羟化作用的影响。在培养过程中，月桂酸羟化活性降低。当肝细胞在添加了10⁻⁵M、10⁻⁴M和10⁻³M氯贝丁酯的情况下培养72小时时，月桂酸羟化分别增加了42%、428%和900%。乙醇的刺激作用也很显著。向培养基中同时添加乙醇和氯贝丁酯会增强这种诱导作用。
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