Stringer K A, Hicks P, Royal S H, Branconi J M, Sloan R
Clinical Pharmacokinetics Laboratory, Millard Fillmore Hospital, Buffalo, NY 14209.
Drug Intell Clin Pharm. 1988 Jul-Aug;22(7-8):575-6. doi: 10.1177/106002808802200712.
Verapamil has been shown to be effective in the management of supraventricular tachycardia (SVT). However, the utility of verapamil may be limited because of adverse effects, specifically hypotension. Several clinical observations have shown that the intravenous administration of calcium is effective in reversing the myocardial depressant effects of verapamil. We report the case of a patient with SVT and a systolic blood pressure of 80 mm Hg in which the administration of calcium chloride prior to that of verapamil may have negated verapamil-induced hypotension.
维拉帕米已被证明在室上性心动过速（SVT）的治疗中有效。然而，由于不良反应，特别是低血压，维拉帕米的效用可能会受到限制。一些临床观察表明，静脉注射钙剂可有效逆转维拉帕米的心肌抑制作用。我们报告了一例室上性心动过速且收缩压为80毫米汞柱的患者，在给予维拉帕米之前先给予氯化钙可能抵消了维拉帕米引起的低血压。
