Child and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children's Hospital, I.R.C.C.S, Rome, Italy; Department of Human Science, LUMSA University of Rome, Rome, Italy.
Child and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children's Hospital, I.R.C.C.S, Rome, Italy.
Prog Brain Res. 2021;264:191-210. doi: 10.1016/bs.pbr.2021.01.015.
Developmental Dyslexia (DD) significantly interferes with academic, personal, social and emotional functioning. Nevertheless, established therapeutic options are still scarce. Research has begun to emerge studying the potential action of transcranial direct current stimulation (tDCS) for ameliorating reading. However, there are still open questions regarding the most suitable tDCS protocol in young with DD. The current study tested the effectiveness of a short, intensive and multi-session tDCS protocol and presented preliminary data from a randomized sham-controlled crossover trial. Twenty-seven children and adolescents with DD were randomly assigned to active tDCS or sham tDCS. Active tDCS group received five daily-consecutive sessions of left anodal/right cathodal set at 1mA for 20min over parieto-occipital regions. Reading measures, including text, high frequency word, low frequency word and non-word lists, were recorded before, immediately after the treatment and 1-week later. We found that only the active tDCS group ameliorated non-word reading speed immediately after and 1-week later the end of the treatment compared to the baseline. Some suggestions for the development of future tDCS protocols in children and adolescents with DD are given.
发展性阅读障碍（DD）严重干扰了患者的学术、个人、社会和情感功能。尽管如此，现有的治疗方法仍然很少。目前已经有研究开始探索经颅直流电刺激（tDCS）在改善阅读方面的潜在作用。然而，对于 DD 青少年最适合的 tDCS 方案仍存在一些尚未解决的问题。本研究测试了一种短时间、密集和多疗程 tDCS 方案的有效性，并提供了一项随机假刺激对照交叉试验的初步数据。27 名患有 DD 的儿童和青少年被随机分配到真刺激 tDCS 组或假刺激 tDCS 组。真刺激 tDCS 组接受 5 天连续的左阳极/右阴极刺激，电流强度为 1mA，持续 20 分钟，刺激部位为顶枕叶区域。在治疗前、治疗后立即和治疗结束后 1 周，记录阅读测试结果，包括文本、高频词、低频词和非词列表。我们发现，只有真刺激 tDCS 组在治疗结束后立即和 1 周后改善了非词阅读速度，与基线相比有所提高。对于未来 DD 儿童和青少年的 tDCS 方案的制定，我们提出了一些建议。
