1Department of Feed Safety, Institute of Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, Páter K. u. 1, H-2103, Gödöllő, Hungary.
2MTA-KE-SZIE Mycotoxins in the Food Chain Research Group, Kaposvár University, Kaposvár, Hungary.
Acta Vet Hung. 2021 Jun 23;69(2):125-133. doi: 10.1556/004.2021.00021.
The purpose of the present study was to investigate the effects of different dietary concentrations of ochratoxin A (OTA) on the growth, feed intake, mortality, blood plasma protein content and some parameters of lipid peroxidation and the glutathione redox system of pheasant chicks in a three-week long trial. A total of 320 seven-day-old female pheasants were randomly assigned to four treatment groups (n = 40 in each), fed with a diet artificially contaminated with OTA [control (<0.02 mg/kg), 0.88 mg/kg, 1.14 mg/kg and 1.51 mg/kg] for 21 days (up to 28 days of age). The pheasant chicks were sacrificed at early (12, 24 and 72 h) and late (7, 14 and 21 days) stages of mycotoxin exposure to check the effect of OTA. Minimal feed refusal was found in the medium- and high-dose toxin groups (-9.8 and -7.9%, respectively), and body weight gain was nearly the same in all groups. The glutathione redox system was activated mainly in the liver, confirmed by significantly increased reduced glutathione content and glutathione peroxidase activity during the late phase of mycotoxin exposure and at a high-dose treatment. The results suggest that pheasants have low susceptibility to OTA, and activation of the glutathione redox system has importance in this tolerance.
本研究旨在探讨在为期三周的试验中，不同膳食浓度的赭曲霉毒素 A（OTA）对雉鸡生长、饲料摄入量、死亡率、血浆蛋白含量以及脂质过氧化和谷胱甘肽氧化还原系统的一些参数的影响。将 320 只 7 日龄雌性雉鸡随机分配到四个处理组（每组 40 只），用人工污染 OTA 的饲料喂养 [对照（<0.02mg/kg）、0.88mg/kg、1.14mg/kg 和 1.51mg/kg] 21 天（至 28 日龄）。在霉菌毒素暴露的早期（12、24 和 72 小时）和晚期（7、14 和 21 天）阶段，牺牲雉鸡以检查 OTA 的影响。中剂量和高剂量毒素组的采食量最低（分别为-9.8%和-7.9%），所有组的体重增加几乎相同。谷胱甘肽氧化还原系统主要在肝脏中被激活，这在霉菌毒素暴露的后期和高剂量处理时，还原型谷胱甘肽含量和谷胱甘肽过氧化物酶活性显著增加得到证实。结果表明，雉鸡对 OTA 的敏感性较低，谷胱甘肽氧化还原系统的激活在这种耐受性中具有重要意义。
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