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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Werber I, Horowitz M

Division of Physiology, Hadassah School of Dental Medicine, Hebrew University, Jerusalem, Israel.

Gen Pharmacol. 1988;19(3):381-6. doi: 10.1016/0306-3623(88)90033-x.

The effect of Arginine-Vasopressin (AVP) and phenoxybenzamine on regional sequestration of albumin in the extracellular space was studied in anesthetized (Na-Thiopentone) rats using a dual albumin labelling technique. 2. Low AVP dose (400 microU/kg) resulted in increased albumin sequestration, particularly in cutaneous and skeletal muscle extravascular space. In higher AVP doses this effect was not pronounced. 3. Phenoxybenzamin resulted in increased albumin sequestration, mostly in cutaneous and skeletal muscle extravascular space. 4. The effect of AVP, a potent pressoric hormone, on albumin sequestration resembles that of a vasodilator drug and contrasts with its pressoric nature.

使用双白蛋白标记技术，在麻醉（硫喷妥钠）大鼠中研究了精氨酸加压素（AVP）和酚苄明对细胞外空间白蛋白区域隔离的影响。2. 低剂量AVP（400微单位/千克）导致白蛋白隔离增加，特别是在皮肤和骨骼肌血管外空间。高剂量AVP时这种效应不明显。3. 酚苄明导致白蛋白隔离增加，主要在皮肤和骨骼肌血管外空间。4. AVP作为一种强效加压激素，对白蛋白隔离的影响类似于血管扩张剂药物，与其加压性质形成对比。

Werber I, Horowitz M

Division of Physiology, Hadassah School of Dental Medicine, Hebrew University, Jerusalem, Israel.

Gen Pharmacol. 1988;19(3):381-6. doi: 10.1016/0306-3623(88)90033-x.

The effect of Arginine-Vasopressin (AVP) and phenoxybenzamine on regional sequestration of albumin in the extracellular space was studied in anesthetized (Na-Thiopentone) rats using a dual albumin labelling technique. 2. Low AVP dose (400 microU/kg) resulted in increased albumin sequestration, particularly in cutaneous and skeletal muscle extravascular space. In higher AVP doses this effect was not pronounced. 3. Phenoxybenzamin resulted in increased albumin sequestration, mostly in cutaneous and skeletal muscle extravascular space. 4. The effect of AVP, a potent pressoric hormone, on albumin sequestration resembles that of a vasodilator drug and contrasts with its pressoric nature.

使用双白蛋白标记技术，在麻醉（硫喷妥钠）大鼠中研究了精氨酸加压素（AVP）和酚苄明对细胞外空间白蛋白区域隔离的影响。2. 低剂量AVP（400微单位/千克）导致白蛋白隔离增加，特别是在皮肤和骨骼肌血管外空间。高剂量AVP时这种效应不明显。3. 酚苄明导致白蛋白隔离增加，主要在皮肤和骨骼肌血管外空间。4. AVP作为一种强效加压激素，对白蛋白隔离的影响类似于血管扩张剂药物，与其加压性质形成对比。