Gut endocrine cells in the snail Helix aspersa.

A microscopic study of the endocrine cells present in the gut of the snail Helix aspersa is made. Electron microscopy is necessary in most cases to identify the enteroendocrine cells, since neither silver impregnations nor immunocytochemical staining have rendered positive results. Endocrine cells are scarce and rest on the basement membrane. They display a clear cytoplasm and variable amounts of small (143 nm) secretory granules of diverse electron-density. They are ovoid or rounded and possess apical processes which extend into the lumen of the gut. The nucleus, located in the basal region of the cell, presents characteristic cytoplasmic indentations. Intraepithelial nerve bundles in contact with endocrine cells are present.