Brigham and Women's Hospital, Boston, MA, USA.
Massachusetts General Hospital, Boston, MA, USA.
Alzheimers Res Ther. 2021 Jun 25;13(1):118. doi: 10.1186/s13195-021-00856-x.
Impaired self-awareness of memory function, a.k.a. anosognosia, is a common symptom in Alzheimer's disease (AD); however, its pathological correlates remain unclear. Here, we investigated the impact of amyloid and tau on memory self-awareness.
Two hundred thirty-six clinically normal (N) and 102 impaired (I) participants from the ADNI cohort were included. Amyloid (global) and tau burden (in entorhinal and inferior temporal cortices) were assessed using positron emission tomography (PET). Self-awareness of memory was assessed using discrepancy indexes of subjective participant-informant ratings, as well as participant-objective scores of memory performance. Subjective and objective values were derived from the Everyday Cognition memory questionnaire and Logical Memory (delayed recall).
Lower awareness (both methods) of memory function was associated with higher levels of pathology in the I group as compared to N. There was a significant effect of tauopathy, but not amyloidosis, on individual complaint, such that higher levels of tau associated with lower awareness.
Impaired self-awareness appears progressively in the evolution of the disease related to AD biomarkers. Discordant subjective and objective measures may be important for clinical consideration.
记忆功能自我意识受损，又称健忘症，是阿尔茨海默病（AD）的常见症状；然而，其病理相关性仍不清楚。在这里，我们研究了淀粉样蛋白和 tau 对记忆自我意识的影响。
我们纳入了来自 ADNI 队列的 236 名临床正常（N）和 102 名受损（I）参与者。使用正电子发射断层扫描（PET）评估淀粉样蛋白（整体）和 tau 负担（在内嗅皮质和下颞叶皮质）。使用主观参与者-告知者评分的差异指数以及记忆表现的参与者-客观评分来评估记忆自我意识。主观和客观值源自日常认知记忆问卷和逻辑记忆（延迟回忆）。
与 N 组相比，I 组的记忆功能较低的意识（两种方法）与更高水平的病理相关。tau 病与个体抱怨有显著的相关性，但淀粉样蛋白病没有，即较高水平的 tau 与较低的意识相关。
在 AD 生物标志物相关疾病的发展过程中，自我意识受损似乎逐渐出现。不一致的主观和客观测量可能对临床考虑很重要。
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