E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
National Research Tomsk State University, Tomsk, Russia.
Bull Exp Biol Med. 2021 May;171(2):212-217. doi: 10.1007/s10517-021-05197-1. Epub 2021 Jun 26.
Using rat and mouse models of neurogenic, ethanol-induced, and indometacin-induced damage to the gastric mucosa we demonstrated that course preventive treatment with flavonoid complex from aerial parts of Lychnis chalcedonica L. increased the resistance of gastric mucosa to ulcerogenic factors of different etiology. The gastroprotective effect of the phytocomplex in a dose range of 16-1600 μg/kg was comparable with that of the reference drug plantaglucide and was superior to that of the reference drugs eleutherococcus extract and methyluracil in the therapeutic doses. The antiulcerogenic activity of Lychnis chalcedonica flavonoid complex considerably exceeded activity of Lychnis chalcedonica L. extract demonstrated in our previous experiments.
使用神经源性、乙醇诱导和吲哚美辛诱导的大鼠和小鼠模型胃黏膜损伤，我们证明了用矢车菊地上部分的黄酮类复合物进行预防性治疗可增加胃黏膜对不同病因致溃疡因子的抵抗力。该植物复合物在 16-1600μg/kg 的剂量范围内表现出的胃保护作用与参考药物车前苷相当，并且在治疗剂量下优于参考药物刺五加提取物和甲基尿嘧啶。与我们之前的实验中所展示的矢车菊提取物相比，矢车菊黄酮类复合物的抗溃疡活性显著增强。
