脊柱侧凸的遗传动物模型：系统评价。

Genetic animal models of scoliosis: A systematical review.

机构信息

Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China.

出版信息

Bone. 2021 Nov;152:116075. doi: 10.1016/j.bone.2021.116075. Epub 2021 Jun 24.

DOI:10.1016/j.bone.2021.116075

Abstract

Scoliosis is a complex disease with undetermined pathogenesis and has a strong relationship with genetics. Models of scoliosis in animals have been established for better comprehending its pathogenesis and treatment. In this review, we searched all the genetic animal models with body curvature in databases, and reviewed the related genes and scoliosis types. Meanwhile, we also summarized the pathogenesis of scoliosis reported so far. Summarizing the positive phenotypic animal models contributes to a better understanding on the pathogenesis of scoliosis and facilitates the selection of experimental models when a possible pathogenic factor is concerned.

摘要

脊柱侧凸是一种发病机制不明的复杂疾病，与遗传有很强的关系。为了更好地理解其发病机制和治疗方法，已经在动物中建立了脊柱侧凸模型。在这篇综述中，我们在数据库中搜索了所有具有身体弯曲的遗传动物模型，并回顾了相关基因和脊柱侧凸类型。同时，我们还总结了迄今为止报道的脊柱侧凸发病机制。总结阳性表型动物模型有助于更好地理解脊柱侧凸的发病机制，并在关注可能的致病因素时，方便实验模型的选择。