Kouwenhoven Jan-Willem M, Castelein René M
Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Spine (Phila Pa 1976). 2008 Dec 15;33(26):2898-908. doi: 10.1097/BRS.0b013e3181891751.
Review of the literature on the pathogenesis of adolescent idiopathic scoliosis (AIS).
To discuss the different theories that have appeared on this subject.
The pathogenesis of AIS, a condition exclusive to humans, has been the subject of many studies. Over the years, practically every structure of the body has been mentioned in the pathogenesis of AIS; however, the cause of this spinal deformity remains little understood. The pathogenesis of this condition is termed multifactorial.
PubMed and Google Scholar electronic databases were searched focused on parameters concerning the pathogenesis of adolescent idiopathic scoliosis. The search was limited to the English language.
No single causative factor for the development of idiopathic scoliosis has been identified, it is thus termed multifactorial. AIS is a complex genetic disorder. The fully erect posture, which is unique to humans, seems to be a prerequisite for the development of AIS.
Although any or all of the mentioned factors in this review may play a certain role in the initiation and progression of AIS at a certain stage, the presented material suggests that in the observed deformation, genetics, and the unique mechanics of the fully upright human spine play a decisive role.
对青少年特发性脊柱侧凸（AIS）发病机制的文献综述。
探讨关于该主题出现的不同理论。
AIS是人类特有的一种疾病，其发病机制一直是众多研究的主题。多年来，几乎身体的每个结构都在AIS的发病机制中被提及；然而，这种脊柱畸形的病因仍知之甚少。这种疾病的发病机制被称为多因素的。
在PubMed和谷歌学术电子数据库中进行搜索，重点关注与青少年特发性脊柱侧凸发病机制相关的参数。搜索限于英文文献。
尚未确定特发性脊柱侧凸发展的单一致病因素，因此称之为多因素的。AIS是一种复杂的遗传疾病。人类特有的完全直立姿势似乎是AIS发展的一个先决条件。
尽管本综述中提到的任何或所有因素可能在AIS发病和进展的某个阶段发挥一定作用，但所呈现的资料表明，在观察到的畸形中，遗传学以及人类完全直立脊柱的独特力学起决定性作用。
