Department of Psychology and Program in Neuroscience, St. Lawrence University, United States.
Department of Psychology and Program in Neuroscience, St. Lawrence University, United States.
Behav Processes. 2021 Sep;190:104449. doi: 10.1016/j.beproc.2021.104449. Epub 2021 Jun 24.
The CNTNAP2 gene has been implicated in several neuropsychological disorders, including autism spectrum disorder (ASD) and schizophrenia. The CNTNAP2 knockout (KO) rat model, rats without the CNTNAP2 gene, exhibits deficits in social interaction and increases in both repetitive and anxiety-like behaviors. However, deficits in time perception that may underlie several of the neuropsychological disorders implicated have not been investigated. The current study investigated timing in CNTNAP2 KO rats compared to control rats using a discrete-trial temporal bisection task. Results suggested deficits in the timing of relatively long durations in the CNTNAP2 KO rats. This finding is consistent with similar findings previously reported in humans diagnosed with ASD, and is promising for understanding the role that the CNTNAP2 gene may play in timing in certain neuropsychological disorders, and for developing targeted clinical therapies.
CNTNAP2 基因与多种神经心理障碍有关，包括自闭症谱系障碍（ASD）和精神分裂症。CNTNAP2 基因敲除（KO）大鼠模型，即没有 CNTNAP2 基因的大鼠，表现出社交互动缺陷，以及重复性和焦虑样行为增加。然而，尚未研究可能是几种涉及的神经心理障碍的基础的时间知觉缺陷。本研究使用离散试验时间二分法任务，比较了 CNTNAP2 KO 大鼠与对照大鼠的时间知觉。结果表明，CNTNAP2 KO 大鼠在较长时间的定时方面存在缺陷。这一发现与先前在被诊断为 ASD 的人类中报告的类似发现一致，有望理解 CNTNAP2 基因在某些神经心理障碍中的定时作用，并为开发有针对性的临床治疗方法提供帮助。
