Department of Otolaryngology, College of Medicine, University of Florida, Gainesville, FL, USA.
Department of Otolaryngology, College of Medicine, University of Florida, Gainesville, FL, USA.
Int J Pediatr Otorhinolaryngol. 2021 Aug;147:110805. doi: 10.1016/j.ijporl.2021.110805. Epub 2021 Jun 24.
Commercial quinolone ear drops (0.3%) delivered twice daily for 10 days cause tympanic membrane perforations (TMPs) in rats. We aimed to evaluate if a single application of 6% quinolone in poloxamer causes TMPs in rats.
Rats were randomized to 5 groups (10/group), with one ear receiving a single otic instillation of 16% poloxamer 407 or 188 (as found in a commercial otic preparation and a wound dressing), or ofloxacin, ciprofloxacin, or neomycin at 6% in suspension with 16% poloxamer 407. The contralateral ear received saline. Rats were assessed over 42 days.
No TMPs were seen in ears treated with saline, poloxamer 407 or 188, or in ears treated with ofloxacin-, ciprofloxacin-, or neomycin-poloxamer suspension. White precipitates were observed on the canal or tympanic membrane of ciprofloxacin and ofloxacin-treated ears. Precipitates were more common in ciprofloxacin-treated ears until day 10 (p < 0.0001 to p = 0.0004). Tympanic membrane surface irregularities, were also observed mostly in the ciprofloxacin-treated ears from day 3-42 (p = 0.03 to p = 0.0033).
Quinolone in poloxamer otic preparations may be a safer therapeutic alternative to conventional quinolone ear drops in ears with intact TMs, particularly those felt to be at risk for developing TMPs.
商业化的喹诺酮滴耳液（0.3%），每日两次，连续使用 10 天，会导致大鼠鼓膜穿孔（TMP）。我们旨在评估单剂量 6%的喹诺酮在泊洛沙姆中的应用是否会导致大鼠 TMP。
大鼠随机分为 5 组（每组 10 只），一侧耳朵接受 16%泊洛沙姆 407 或 188（存在于一种商业滴耳液和一种伤口敷料中）或氧氟沙星、环丙沙星、或新霉素的 6%混悬液的单次耳内滴注。对侧耳朵接受生理盐水。大鼠在 42 天内进行评估。
接受生理盐水、泊洛沙姆 407 或 188 治疗的耳朵，或接受氧氟沙星、环丙沙星或新霉素-泊洛沙姆混悬液治疗的耳朵均未出现 TMP。在接受环丙沙星和氧氟沙星治疗的耳朵的耳道或鼓膜上观察到白色沉淀物。沉淀物在接受环丙沙星治疗的耳朵中更为常见，直至第 10 天（p<0.0001 至 p=0.0004）。从第 3 天到第 42 天，也主要在接受环丙沙星治疗的耳朵中观察到鼓膜表面不规则（p=0.03 至 p=0.0033）。
在鼓膜完整的耳朵中，与传统的喹诺酮滴耳液相比，泊洛沙姆中的喹诺酮滴耳液可能是一种更安全的治疗选择，特别是对于那些有发生 TMP 风险的耳朵。
