John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, USA.
J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211028389. doi: 10.1177/23247096211028389.
Stroke is an identified sequela of severe coronavirus disease 2019 (COVID-19) infection. While the pathophysiology remains poorly understood, endothelial dysfunction and intravascular thrombosis secondary to sepsis-induced hypercoagulability likely increase the risk of stroke. This report describes the rare case of an otherwise healthy 42-year-old male who developed large bilateral ischemic infarcts during admission for severe hypoxemic respiratory failure secondary to COVID pneumonia. This report adds to scarce literature describing massive cerebrovascular injury in COVID patients and emphasizes the importance of increased clinical suspicion for stroke in patients who exhibit acute change in mental status or motor function, as well as rapid clinical deterioration.
中风是严重 2019 年冠状病毒病(COVID-19)感染的明确后遗症。尽管其病理生理学仍知之甚少,但败血症引起的高凝状态继发的内皮功能障碍和血管内血栓形成可能会增加中风的风险。本报告描述了一例罕见病例,一名原本健康的 42 岁男性,因 COVID 肺炎导致严重低氧性呼吸衰竭住院期间发生双侧大面积缺血性梗死。本报告补充了描述 COVID 患者发生大量脑血管损伤的罕见文献,并强调了对出现急性精神状态或运动功能改变以及快速临床恶化的患者提高对中风的临床怀疑的重要性。