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COVID-19 患者以缺血性卒中为首发表现:巴西急诊病例系列评估。

Ischaemic stroke as an initial presentation in patients with COVID-19: evaluation of a case series in an emergency in Brazil.

机构信息

Department of Radiology, Fortaleza General Hospital, Brazil.

出版信息

Neuroradiol J. 2021 Aug;34(4):308-312. doi: 10.1177/1971400920987357. Epub 2021 Jan 18.

DOI:10.1177/1971400920987357
PMID:33455541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8447816/
Abstract

The disease caused by the new coronavirus, initially described in China in December 2019, became known as coronavirus disease 2019 and quickly spread to countries on all continents, becoming a pandemic with an important global impact. Despite being a virus that typically affects the respiratory tract, some studies have already described neurological manifestations associated with this infection, including acute ischaemic vascular insult. We report a case series including 30 patients, who presented with neurological symptoms during admission to our service, being diagnosed with ischaemic stroke and, concomitantly, coronavirus disease 2019. In the subgroup of patients analysed, a state of hypercoagulability and pro thrombosis was observed through laboratory tests, probably related to the cytokine storm syndrome associated with infection by this virus. With that, we discussed the possibility of this finding being an aggravating factor in the occurrence of stroke in these patients.

摘要

这种由新型冠状病毒引起的疾病最初于 2019 年 12 月在中国被描述,被称为 2019 年冠状病毒病,并迅速传播到各大洲的国家,成为具有重要全球影响的大流行。尽管这是一种通常影响呼吸道的病毒,但一些研究已经描述了与这种感染相关的神经表现,包括急性缺血性血管损伤。我们报告了一个包括 30 例患者的病例系列,这些患者在入住我们的服务时出现了神经系统症状,被诊断为缺血性中风,同时患有 2019 年冠状病毒病。在分析的患者亚组中,通过实验室检查观察到一种高凝状态和血栓形成前状态,这可能与感染这种病毒相关的细胞因子风暴综合征有关。因此,我们讨论了这种发现是否是这些患者中风发生的加重因素的可能性。

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Stroke Vasc Neurol. 2020 Sep;5(3):279-284. doi: 10.1136/svn-2020-000431. Epub 2020 Jul 2.
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COVID-19 critical illness pathophysiology driven by diffuse pulmonary thrombi and pulmonary endothelial dysfunction responsive to thrombolysis.由弥漫性肺血栓和对溶栓有反应的肺内皮功能障碍驱动的COVID-19危重病病理生理学。
Clin Transl Med. 2020 Jun;10(2):e44. doi: 10.1002/ctm2.44. Epub 2020 Jun 5.
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Neuroradiologists, Be Mindful of the Neuroinvasive Potential of COVID-19.神经放射科医生,请注意新型冠状病毒肺炎的神经侵袭潜力。
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