1Department of Urology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Department of Pathology, Dr Josip Benčević General Hospital, Slavonski Brod, Croatia; 3Department of Urology, Dr Josip Benčević General Hospital, Slavonski Brod, Croatia; 4School of Medicine, University of Zagreb, Zagreb, Croatia; 5Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb University Hospital Centre, Zagreb, Croatia.
Acta Clin Croat. 2020 Sep;59(3):539-542. doi: 10.20471/acc.2020.59.03.20.
Although collecting duct carcinoma is a subtype of renal cell carcinoma, several studies implicate association with urothelial carcinoma. The coexistence of collecting duct carcinoma and another renal neoplasm is rare. Endemic nephropathy is a renal disease causing chronic renal failure. It is highly associated with urothelial neoplasm and occurs in endemic villages in Bosnia, Croatia, Bulgaria, Romania and Serbia. Recent studies have confirmed the important role of exposure to aristolochic acid as an etiologic factor. We present three cases of collecting duct carcinoma with literature overview. In one case, we describe collecting duct carcinoma with metachronous urothelial carcinoma of the pyelon and urinary bladder in an endemic nephropathy patient. To our knowledge, this is the first case report describing this coexistence. Certain similarities between collecting duct carcinoma and urothelial carcinoma were found, e.g., higher incidence in female compared to male, higher mean age, and multifocal and multicentric occurrence of the tumor. Our observations support the hypothesis that collecting duct carcinoma and urothelial carcinoma could be connected.
虽然集合管癌是肾细胞癌的一种亚型，但有几项研究表明其与尿路上皮癌有关。集合管癌与另一种肾肿瘤并存的情况很少见。地方性肾病是一种导致慢性肾衰竭的肾脏疾病。它与尿路上皮肿瘤高度相关，发生在波斯尼亚、克罗地亚、保加利亚、罗马尼亚和塞尔维亚的地方性村庄。最近的研究证实了接触马兜铃酸作为病因的重要作用。我们报告了三例集合管癌病例，并进行了文献回顾。在一个病例中，我们描述了一名患有地方性肾病的患者同时患有肾盂和膀胱的移行细胞癌。据我们所知，这是首例描述这种共存的病例报告。我们发现集合管癌和尿路上皮癌之间存在某些相似之处，例如，女性发病率高于男性，平均年龄较高，肿瘤多灶性和多中心发生。我们的观察结果支持这样一种假设，即集合管癌和尿路上皮癌可能有关联。
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