Belicza Mladen, Demirović Alma, Tomić Karla, Lenicek Tanja, Pavić Ivana, Jakovina Krunoslav, Vukelić Mato, Jakovina Tratincica, Misić Maja, Kruslin Bozo
University Department of Pathology "Ljudevit Jurak", University Hospital "Sestre milosrdnice", Zagreb, Croatia.
Coll Antropol. 2008 Dec;32(4):1203-7.
Balkan endemic nephropathy (BEN) is a chronic tubulointerstitial renal disease of a still unknown etiology, associated with an increased frequency of urothelial carcinoma, particularly of the upper urinary tract (UUT). The aim of the study was to compare the occurrence of UUT carcinomas between Brodsko-Posavska Region (BPR) which is the region with endemic villages and the non-endemic region of Zagreb (ZG) in two six-year periods with a 20 year period separating the two, pointing out a possible difference in occurrence regarding war in Croatia (1991-1995). Comparing BPR and ZG regions we found a more then 5 times higher frequency of UUT carcinomas in BPR in the first period and more than 4.5 times higher frequency in the second period. Women in BPR were more frequently affected with UUT carcinomas.
巴尔干地方性肾病（BEN）是一种病因仍不明的慢性肾小管间质性肾病，与尿路上皮癌尤其是上尿路（UUT）癌的发病率增加有关。本研究的目的是比较在两个六年期内，有地方性流行村庄的布罗德斯科-波萨夫斯卡地区（BPR）和萨格勒布非地方性流行地区（ZG）的上尿路癌发病率，两个时期相隔20年，并指出克罗地亚战争（1991 - 1995年）期间发病率可能存在的差异。比较BPR和ZG地区，我们发现第一期BPR的上尿路癌发病率高出5倍多，第二期高出4.5倍多。BPR地区的女性受上尿路癌影响更为频繁。
