Fadiran E O, Davidson A G
Department of Pharmacy, School of Pharmacy and Pharmacology, University of Strathclyde, Glasgow, U.K.
J Chromatogr. 1988 Jun 17;442:363-70. doi: 10.1016/s0021-9673(00)94484-4.
A thin-layer chromatographic-second derivative spectrofluorimetric procedure has been developed for low levels of sulphoxide (down to 0.01%, w/w) in phenothiazine drug substances and formulations. The method has been applied to prochlorperazine maleate, chlorpromazine hydrochloride and promethazine hydrochloride. It has also been applied to pharmaceutical formulations of promethazine hydrochloride and comparison of the results with those obtained by a published difference spectrophotometric procedure for promethazine sulphoxide showed that there was good agreement. The method is simple, rapid, accurate and precise and seems to have general application to the determination of low levels of sulphoxide in phenothiazine drug substances or formulations.
已开发出一种薄层色谱 - 二阶导数荧光分光光度法，用于测定吩噻嗪类原料药及制剂中低含量的亚砜（低至0.01%，w/w）。该方法已应用于马来酸氯丙嗪、盐酸氯丙嗪和盐酸异丙嗪。它也已应用于盐酸异丙嗪的药物制剂，并且将结果与通过已发表的用于测定异丙嗪亚砜的差示分光光度法所获得的结果进行比较，结果显示二者吻合良好。该方法简单、快速、准确且精密，似乎普遍适用于测定吩噻嗪类原料药或制剂中低含量的亚砜。
