一名转移性肾细胞癌患者出现的与帕博利珠单抗相关的血清阴性重症肌无力
Pembrolizumab-Associated Seronegative Myasthenia Gravis in a Patient With Metastatic Renal Cell Carcinoma.
作者信息
Pandya Shaunak K, Ulrickson Matthew, Dong JiaXi, Willen Ryan, Pandya Arati
机构信息
Internal Medicine, Banner - University Medical Center Phoenix, University of Arizona College of Medicine - Phoenix, Phoenix, USA.
Hematology and Oncology, Stem Cell Transplant, Banner MD Anderson Cancer Center, Gilbert, USA.
出版信息
Cureus. 2021 May 22;13(5):e15174. doi: 10.7759/cureus.15174.
Abstract
Seronegative myasthenia gravis is a rare, but potential adverse effect of immune checkpoint inhibition. There have been few but increasing number of cases reported in recent years, and early recognition is important for prompt diagnosis and management. Here, we describe the case of a 65-year-old male with metastatic renal cell carcinoma on pembrolizumab diagnosed with new-onset seronegative myasthenia gravis and review literature on its management.
摘要
血清阴性重症肌无力是一种罕见但免疫检查点抑制的潜在不良反应。近年来报告的病例虽少但数量在增加，早期识别对于及时诊断和管理很重要。在此，我们描述了一名65岁男性转移性肾细胞癌患者，其接受帕博利珠单抗治疗后被诊断为新发血清阴性重症肌无力，并回顾了关于其管理的文献。
相似文献
1
Pembrolizumab-Associated Seronegative Myasthenia Gravis in a Patient With Metastatic Renal Cell Carcinoma.一名转移性肾细胞癌患者出现的与帕博利珠单抗相关的血清阴性重症肌无力
Cureus. 2021 May 22;13(5):e15174. doi: 10.7759/cureus.15174.
2
Pembrolizumab-Induced Myasthenia Gravis With Myocarditis in the Setting of Metastatic Renal Cell Carcinoma.帕博利珠单抗诱导的重症肌无力合并心肌炎伴转移性肾细胞癌
Cureus. 2024 Aug 31;16(8):e68318. doi: 10.7759/cureus.68318. eCollection 2024 Aug.
3
Myasthenia gravis with myositis induced by pembrolizumab therapy in a patient with metastatic urothelial carcinoma.帕博利珠单抗治疗转移性尿路上皮癌患者诱发重症肌无力合并肌炎
Int Cancer Conf J. 2020 Mar 21;9(3):123-126. doi: 10.1007/s13691-020-00408-4. eCollection 2020 Jul.
4
Pembrolizumab-induced myasthenia gravis: A fatal case report.帕博利珠单抗诱发的重症肌无力：一例死亡病例报告。
J Oncol Pharm Pract. 2018 Mar;24(2):146-149. doi: 10.1177/1078155216687389. Epub 2017 Feb 1.
5
A Case of Pembrolizumab-Induced Myasthenia Gravis.一例帕博利珠单抗诱发的重症肌无力病例。
Cureus. 2023 Sep 18;15(9):e45455. doi: 10.7759/cureus.45455. eCollection 2023 Sep.
6
[Re-Administration of Pembrolizumab for Urothelial Carcinoma after immune-Related Myasthenia Gravis : A Case Report].[帕博利珠单抗在免疫相关性重症肌无力后用于尿路上皮癌的再次给药：一例报告]
Hinyokika Kiyo. 2022 Sep;68(9):295-300. doi: 10.14989/ActaUrolJap_68_9_295.
7
Myocarditis and myasthenia gravis by combined nivolumab and ipilimumab immunotherapy for renal cell carcinoma: A case report of successful management.纳武单抗和伊匹单抗联合免疫疗法治疗肾细胞癌并发心肌炎和重症肌无力：成功治疗的病例报告
Urol Case Rep. 2020 Nov 28;34:101508. doi: 10.1016/j.eucr.2020.101508. eCollection 2021 Jan.
8
Myasthenia Gravis Associated With Programmed Death-1 (PD-1) Receptor Inhibitor Pembrolizumab: A 40-day Case Report.与程序性死亡-1（PD-1）受体抑制剂帕博利珠单抗相关的重症肌无力：一例40天病例报告
J Pharm Pract. 2021 Feb;34(1):166-170. doi: 10.1177/0897190020970750. Epub 2020 Nov 4.
9
[A Case of Metastatic Ureteral Cancer Treated with Pembrolizumab without Relapse of Ocular Myasthenia Gravis].[一例用帕博利珠单抗治疗的转移性输尿管癌患者，眼重症肌无力未复发]
Hinyokika Kiyo. 2022 Dec;68(12):377-383. doi: 10.14989/ActaUrolJap_68_12_377.
10
Autoimmune Myasthenia, Primary Adrenal Insufficiency, and Progressive Hypothyroidism Due to Pembrolizumab and Axitinib Combination Regimen.帕博利珠单抗与阿昔替尼联合方案导致的自身免疫性肌无力、原发性肾上腺功能不全和进行性甲状腺功能减退
Cureus. 2021 Aug 6;13(8):e16933. doi: 10.7759/cureus.16933. eCollection 2021 Aug.
引用本文的文献
1
A Case of Myasthenia Gravis: A Paraneoplastic Syndrome or an Immune-Related Disorder?一例重症肌无力：副肿瘤综合征还是免疫相关性疾病？
Cureus. 2025 Feb 6;17(2):e78640. doi: 10.7759/cureus.78640. eCollection 2025 Feb.
2
Myasthenia Gravis as a Paraneoplastic Manifestation of Renal Cell Carcinoma: More Than a Coincidence?重症肌无力作为肾细胞癌的副肿瘤表现：仅是巧合？
Ann Neurosci. 2025 Jan;32(1):47-50. doi: 10.1177/09727531241306852. Epub 2025 Jan 13.
3
Case of Immune Checkpoint Inhibitor Induced Myasthenia Gravis.免疫检查点抑制剂诱发重症肌无力病例
Cureus. 2024 Apr 20;16(4):e58651. doi: 10.7759/cureus.58651. eCollection 2024 Apr.
4
A Case of Pembrolizumab-Induced Myasthenia Gravis.一例帕博利珠单抗诱发的重症肌无力病例。
Cureus. 2023 Sep 18;15(9):e45455. doi: 10.7759/cureus.45455. eCollection 2023 Sep.
5
Multiple Autoimmune Complications After a Single Dose of Pembrolizumab.单剂量帕博利珠单抗后的多种自身免疫并发症
Cureus. 2023 Mar 7;15(3):e35871. doi: 10.7759/cureus.35871. eCollection 2023 Mar.
本文引用的文献
1
Pembrolizumab-induced myasthenia gravis with myositis and presumable myocarditis in a patient with bladder cancer.一名膀胱癌患者发生帕博利珠单抗诱导的重症肌无力伴肌炎及可能的心肌炎。
IJU Case Rep. 2019 Oct 30;3(1):17-20. doi: 10.1002/iju5.12128. eCollection 2020 Jan.
2
Pembrolizumab-Induced Ocular Myasthenic Crisis.帕博利珠单抗诱发的眼肌型重症肌无力危象
Cureus. 2020 Jul 14;12(7):e9192. doi: 10.7759/cureus.9192.
3
Toxicities associated with checkpoint inhibitors-an overview.与检查点抑制剂相关的毒性-概述。
Rheumatology (Oxford). 2019 Dec 1;58(Suppl 7):vii7-vii16. doi: 10.1093/rheumatology/kez418.
4
Development of the Inhibitors that Target the PD-1/PD-L1 Interaction-A Brief Look at Progress on Small Molecules, Peptides and Macrocycles.靶向 PD-1/PD-L1 相互作用的抑制剂的研发——小分子、肽和大环的进展简述。
Molecules. 2019 May 30;24(11):2071. doi: 10.3390/molecules24112071.
5
Pearls & Oy-sters: Pembrolizumab-induced myasthenia gravis.要点与难点：帕博利珠单抗诱发的重症肌无力。
Neurology. 2018 Oct 2;91(14):e1365-e1367. doi: 10.1212/WNL.0000000000006278.
6
Treatment of Myasthenia Gravis.重症肌无力的治疗
Neurol Clin. 2018 May;36(2):311-337. doi: 10.1016/j.ncl.2018.01.011.
7
Use of Immune Checkpoint Inhibitors in the Treatment of Patients With Cancer and Preexisting Autoimmune Disease: A Systematic Review.免疫检查点抑制剂在治疗合并自身免疫性疾病的癌症患者中的应用：系统评价。
Ann Intern Med. 2018 Jan 16;168(2):121-130. doi: 10.7326/M17-2073. Epub 2018 Jan 2.
8
Myasthenia gravis: An emerging toxicity of immune checkpoint inhibitors.重症肌无力：免疫检查点抑制剂的一种新出现的毒性。
Eur J Cancer. 2017 Sep;82:128-136. doi: 10.1016/j.ejca.2017.05.041. Epub 2017 Jun 27.
9
Pembrolizumab-induced myasthenia gravis: A fatal case report.帕博利珠单抗诱发的重症肌无力：一例死亡病例报告。
J Oncol Pharm Pract. 2018 Mar;24(2):146-149. doi: 10.1177/1078155216687389. Epub 2017 Feb 1.
10
Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society.重症肌无力的临床特征、发病机制及治疗：德国神经病学学会指南补编
J Neurol. 2016 Aug;263(8):1473-94. doi: 10.1007/s00415-016-8045-z. Epub 2016 Feb 17.
Zotero 插件