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心肌细胞摄取油酸是由载体介导的，涉及一种40kD的质膜脂肪酸结合蛋白，类似于肝脏、脂肪组织和肠道中的那种蛋白。

Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut.

作者信息

Sorrentino D, Stump D, Potter B J, Robinson R B, White R, Kiang C L, Berk P D

机构信息

Department of Medicine, Mount Sinai School of Medicine, New York 10029.

出版信息

J Clin Invest. 1988 Sep;82(3):928-35. doi: 10.1172/JCI113700.

DOI:10.1172/JCI113700
PMID:3417874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC303604/
Abstract

Uptake of [3H]oleate by canine or rat cardiac myocytes is saturable, displays the countertransport phenomenon, and is inhibited by phloretin and trypsin. Cardiac myocytes contain a basic (pI approximately 9.1) 40-kD plasma membrane fatty acid binding protein (FABPPM) analogous to those recently isolated from liver, adipose tissue, and gut, unrelated to the 12-14-kD cytosolic FABP in these same tissues. An antibody to rat liver FABPPM selectively inhibits specific uptake of [3H]oleate by rat heart myocytes at 37 degrees C, but has no influence on nonspecific [3H]oleate uptake at 4 degrees C or on specific uptake of [3H]glucose. Uptake of long-chain free fatty acids by cardiac muscle cells, liver, and adipose tissue and absorption by gut epithelial cells is a facilitated process mediated by identical or closely related plasma membrane FABPs.

摘要

犬或大鼠心肌细胞对[3H]油酸的摄取具有饱和性，呈现反向转运现象，并受根皮素和胰蛋白酶抑制。心肌细胞含有一种碱性（pI约为9.1）的40kD质膜脂肪酸结合蛋白（FABPPM），类似于最近从肝脏、脂肪组织和肠道分离出的蛋白，与这些相同组织中的12 - 14kD胞质FABP无关。大鼠肝脏FABPPM抗体在37℃时选择性抑制大鼠心肌细胞对[3H]油酸的特异性摄取，但对4℃时的非特异性[3H]油酸摄取或[3H]葡萄糖的特异性摄取没有影响。心肌细胞、肝脏和脂肪组织对长链游离脂肪酸的摄取以及肠道上皮细胞的吸收是一个由相同或密切相关的质膜FABP介导的易化过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7de/303604/7c659480f1c9/jcinvest00081-0192-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7de/303604/7c659480f1c9/jcinvest00081-0192-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7de/303604/7c659480f1c9/jcinvest00081-0192-a.jpg

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