18515Unit of Pathology, ASST Spedali Civili di Brescia, Brescia, Italy.
9242Pathology Unit, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy.
Int J Surg Pathol. 2022 Apr;30(2):177-183. doi: 10.1177/10668969211025759. Epub 2021 Jun 28.
Solitary fibrous tumor (SFT) is an uncommon fibroblastic tumor occurring preferentially in the pleura, with a variable clinical course. SFT can arise also in numerous extrathoracic sites and very rarely in the female genital tract, with only scarce reports of uterine SFT. We reported a new uterine SFT arising in a 45-year-old woman, and we performed a systematic review of SFT cases of the uterine corpus interrogating the electronic databases PubMed, Web of Science, and Scopus. We identified only 13 patients diagnosed with SFT of the uterine corpus, including our one. Complete clinical workout at disease presentation showed no evidence of extrauterine spread in all cases, except for 1 patient who presented with metastatic disease. Tumor recurrences/metastases occurred in a minority of the patients and were poorly related to clinicopathological risk factors and patients stratification based on different scoring systems. Since the long-term clinical behavior of uterine SFT is limited and poorly predictable, extended follow-up is recommended also for all cases arising in the uterine corpus.
孤立性纤维瘤（Solitary fibrous tumor，SFT）是一种罕见的成纤维细胞肿瘤，主要发生于胸膜，具有不同的临床病程。SFT 也可发生于许多胸腔外部位，非常罕见于女性生殖道，仅有少数子宫 SFT 的报道。我们报告了一例发生于 45 岁女性的新的子宫 SFT，并通过检索 PubMed、Web of Science 和 Scopus 电子数据库，对子宫体 SFT 病例进行了系统回顾。我们共确定了 13 例诊断为子宫体 SFT 的患者，包括我们的病例。所有患者在疾病表现时的全面临床检查均未显示有子宫外播散的证据，除了 1 例患者存在转移性疾病。少数患者出现肿瘤复发/转移，且与临床病理危险因素及基于不同评分系统的患者分层相关性较差。由于子宫 SFT 的长期临床行为有限且难以预测，因此建议对所有发生于子宫体的病例进行延长随访。
