Ballantyne G H, Modlin I M
Department of Surgery, Yale University School of Medicine, West Haven, Connecticut.
J Clin Gastroenterol. 1988 Aug;10(4):359-64.
The results of treatment of colorectal cancer have improved little over the last 40 years. This reflects both the advanced age of the patients and the advanced stage of the disease at diagnosis. Currently, extensive multimodality, periodic evaluation of patients is advocated following potentially curative resections in the hope that colorectal cancer recurrence will be identified when metastases are isolated and curable. Such efforts, however, have failed to make any substantial impact on survival. At this time, the identification of colorectal cancer at an earlier than usual stage appears to be the only means by which survival can be improved. Despite this, substantially more effort and resources are devoted to the postoperative follow-up of patients with colorectal cancer than to the identification of early curable colorectal cancer. In the current economic climate and with limited medical resources, it may be more appropriate to aim primarily at identifying early curable lesions by more routine colonscopy.
在过去40年里,结直肠癌的治疗结果几乎没有改善。这既反映了患者的高龄,也反映了诊断时疾病的晚期阶段。目前,提倡在进行潜在根治性切除术后,对患者进行广泛的多模式、定期评估,以期在转移灶孤立且可治愈时发现结直肠癌复发。然而,这些努力未能对生存率产生任何实质性影响。此时,在比通常更早的阶段发现结直肠癌似乎是提高生存率的唯一途径。尽管如此,用于结直肠癌患者术后随访的精力和资源,比用于发现早期可治愈的结直肠癌的精力和资源要多得多。在当前的经济形势下,且医疗资源有限,或许主要通过更常规的结肠镜检查来发现早期可治愈病变更为合适。